Evidence map›Paper›PMID 28009278›Full record

ArticleNeuron2016

Dysfunction of Rapid Neural Adaptation in Dyslexia.

Tyler K Perrachione, Stephanie N Del Tufo, Rebecca Winter, Jack Murtagh, Abigail Cyr, Patricia Chang, Kelly Halverson, Satrajit S Ghosh, Joanna A Christodoulou, John D E Gabrieli

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 145 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Rapid decay of perceptual memory in dyslexia.Trends in cognitive sciences · 2026
    Review
  6. Translating the Power of Precision Medicine Into the World of Communication Disorders.Journal of speech, language, and hearing research : JSLHR · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Reduced categorical learning of faces in dyslexia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
  16. Why are listeners hindered by talker variability?Psychonomic bulletin & review · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Adaptation in auditory processing.Physiological reviews · 2023
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tyler K PerrachioneDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: tkp@bu.edu.
Stephanie N Del TufoDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Rebecca WinterMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jack MurtaghMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Abigail CyrMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Patricia ChangMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kelly HalversonMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Satrajit S GhoshResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Joanna A ChristodoulouDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
John D E GabrieliDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: gabrieli@mit.edu.
Massachusetts Institute of Technology · USMcGovern Institute for Brain Research · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
NCRR NIH HHS UL1 RR025758
6 · The paper itself

Abstract

Identification of specific neurophysiological dysfunctions resulting in selective reading difficulty (dyslexia) has remained elusive. In addition to impaired reading development, individuals with dyslexia frequently exhibit behavioral deficits in perceptual adaptation. Here, we assessed neurophysiological adaptation to stimulus repetition in adults and children with dyslexia for a wide variety of stimuli, spoken words, written words, visual objects, and faces. For every stimulus type, individuals with dyslexia exhibited significantly diminished neural adaptation compared to controls in stimulus-specific cortical areas. Better reading skills in adults and children with dyslexia were associated with greater repetition-induced neural adaptation. These results highlight a dysfunction of rapid neural adaptation as a core neurophysiological difference in dyslexia that may underlie impaired reading development. Reduced neurophysiological adaptation may relate to prior reports of reduced behavioral adaptation in dyslexia and may reveal a difference in brain functions that ultimately results in a specific reading impairment.

Indexed as

Adaptation, PhysiologicalAdultAuditory PerceptionBrainCase-Control StudiesDyslexiaFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMemory, Short-TermPhoneticsSpeech PerceptionYoung Adultadaptationdevelopmental disorderdyslexiahumanlanguageneuroimagingreadingrepetition suppressionspeech

Identifiers

PMID28009278
PMCPMC5226639
OpenAlexW2561712047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.