ArticleCell systems2016
Noise Induces Hopping between NF-κB Entrainment Modes.
Article in Cell systems, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Genetic resonance in the p53 signaling network.Cell systems · 2026Article
- Complex multiannual cycles ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Analogue information processing in NF-κB gene regulatory system.Royal Society open science · 2025Article
- Entrainment and multi-stability of the p53 oscillator in human cells.Cell systems · 2024Article
- Article
- Co-imaging of RelA and c-Rel reveals features of NF-κB signaling for ligand discrimination.Cell reports · 2024Article
- Processing stimulus dynamics by the NF-κB network in single cells.Experimental & molecular medicine · 2023Review
- The multiple activations in budding yeast S-phase checkpoint are Poisson processes.PNAS nexus · 2023Article
- Article
- Double knockin mice show NF-κB trajectories in immune signaling and aging.Cell reports · 2022Article
- Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics.Biological cybernetics · 2022Review
- Multi-synchronization and other patterns of multi-rhythmicity in oscillatory biological systems.Interface focus · 2022Review
- Insights on the NF-κB System Using Live Cell Imaging: Recent Developments and Future Perspectives.Frontiers in immunology · 2022Review
- A Review of Mathematical and Computational Methods in Cancer Dynamics.Frontiers in oncology · 2022Review
- Temperature Controls Onset and Period of NF-Frontiers in cell and developmental biology · 2022Article
- Quantifying the optimal strategy of population control of quorum sensing network in Escherichia coli.NPJ systems biology and applications · 2021Article
- Analyzing signaling activity and function in hematopoietic cells.The Journal of experimental medicine · 2021Review
- A review of dynamical systems approaches for the detection of chaotic attractors in cancer networks.Patterns (New York, N.Y.) · 2021Review
- Inferring Leading Interactions in the p53/Mdm2/Mdmx Circuit through Live-Cell Imaging and Modeling.Cell systems · 2019Article
- Low-dimensional Dynamics of Two Coupled Biological Oscillators.Nature physics · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Oscillations and noise drive many processes in biology, but how both affect the activity of the transcription factor nuclear factor κB (NF-κB) is not understood. Here, we observe that when NF-κB oscillations are entrained by periodic tumor necrosis factor (TNF) inputs in experiments, NF-κB exhibits jumps between frequency modes, a phenomenon we call "cellular mode-hopping." By comparing stochastic simulations of NF-κB oscillations to deterministic simulations conducted inside and outside the chaotic regime of parameter space, we show that noise facilitates mode-hopping in all regimes. However, when the deterministic system is driven by chaotic dynamics, hops between modes are erratic and short-lived, whereas in experiments, the system spends several periods in one entrainment mode before hopping and rarely visits more than two modes. The experimental behavior matches our simulations of noise-induced mode-hopping outside the chaotic regime. We suggest that mode-hopping is a mechanism by which different NF-κB-dependent genes under frequency control can be expressed at different times.
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Registered trials
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