ArticleHuman brain mapping2017
Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Modulation of resting-state networks following repetitive transcranial alternating current stimulation of the dorsolateral prefrontal cortex.Brain structure & function · 2023Trial
- The deficit of oligodendrocyte family cells in layer 3 of the dorsal anterior cingulate cortex in schizophrenia: possible interactions with dysfunction and altered microanatomy.European archives of psychiatry and clinical neuroscience · 2026Article
- Understanding Schizophrenia Pathophysiology via fMRI-Based Information Theory and Multiplex Network Analysis.Entropy (Basel, Switzerland) · 2026Article
- Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Exploring the capabilities of repetitive transcranial magnetic stimulation in major depressive disorder: Dynamic causal modeling of the neural network.Translational psychiatry · 2025Article
- Deficit of satellite oligodendrocytes of neurons in the rostral part of the head of the caudate nucleus in schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Association of clozapine with structural and resting-state functional abnormalities of the hippocampus in chronic schizophrenia.Frontiers in psychiatry · 2024Article
- Aberrant Large-Scale Network Interactions Across Psychiatric Disorders Revealed by Large-Sample Multi-Site Resting-State Functional Magnetic Resonance Imaging Datasets.Schizophrenia bulletin · 2023Article
- Widespread Intra- and Inter-Network Dysconnectivity among Large-Scale Resting State Networks in Schizophrenia.Journal of clinical medicine · 2023Article
- Reduced number of satellite oligodendrocytes of pyramidal neurons in layer 5 of the prefrontal cortex in schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
- Moving beyond the 'CAP' of the Iceberg: Intrinsic connectivity networks in fMRI are continuously engaging and overlapping.NeuroImage · 2022Article
- Seed-based dual regression: An illustration of the impact of dual regression's inherent filtering of global signal.Journal of neuroscience methods · 2022Article
- Structural and Functional Characterization of Gray Matter Alterations in Female Patients With Neuropsychiatric Systemic Lupus.Frontiers in neuroscience · 2022Article
- Neural evidence for non-orofacial triggers in mild misophonia.Frontiers in neuroscience · 2022Article
- Effective Connectivity of the Hippocampus Can Differentiate Patients with Schizophrenia from Healthy Controls: A Spectral DCM Approach.Brain topography · 2021Article
- Resting state network functional connectivity abnormalities in systemic lupus erythematosus: correlations with neuropsychiatric impairment.Molecular psychiatry · 2021Article
- Dynamic Causal Modeling Self-Connectivity Findings in the Functional Magnetic Resonance Imaging Neuropsychiatric Literature.Frontiers in neuroscience · 2021Review
- Multi-dimensional predictions of psychotic symptoms via machine learning.Human brain mapping · 2020Article
- Cortical Gyrification, Psychotic-Like Experiences, and Cognitive Performance in Nonclinical Subjects.Schizophrenia bulletin · 2020Article
- Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in functional brain imaging have improved the search for potential endophenotypic markers in schizophrenia. Here, we employed independent component analysis (ICA) and dynamic causal modeling (DCM) in resting state fMRI on a sample of 35 schizophrenia patients, 20 first-degree relatives and 35 control subjects. Analysis on ICA-derived networks revealed increased functional connectivity between the left frontoparietal network (FPN) and left temporal and parietal regions in schizophrenia patients (P < 0.001). First-degree relatives shared this hyperconnectivity, in particular in the supramarginal gyrus (SMG; P = 0.008). DCM analysis was employed to further explore underlying effective connectivity. Results showed increased inhibitory connections to the left angular gyrus (AG) in schizophrenia patients from all other nodes of the left FPN (P < 0.001), and in particular from the left SMG (P = 0.001). Relatives also showed a pattern of increased inhibitory connections to the left AG (P = 0.008). Furthermore, the patient group showed increased excitatory connectivity between the left fusiform gyrus and the left SMG (P = 0.002). This connection was negatively correlated to inhibitory afferents to the left AG (P = 0.005) and to the negative symptom score on the PANSS scale (P = 0.001, r = -0.51). Left frontoparietotemporal dysfunction in schizophrenia has been previously associated with a range of abnormalities, including formal thought disorder, working memory dysfunction and sensory hallucinations. Our analysis uncovered new potential endophenotypic markers of schizophrenia and shed light on the organization of the left FPN in patients and their first-degree relatives. Hum Brain Mapp 38:1741-1750, 2017. © 2017 Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.