Evidence map›Paper›PMID 28008994›Full record

ArticleScientific reports2016

Common germline variants within the CDKN2A/2B region affect risk of pancreatic neuroendocrine tumors.

Daniele Campa, Gabriele Capurso, Manuela Pastore, Renata Talar-Wojnarowska, Anna Caterina Milanetto, Luca Landoni, Evaristo Maiello, Rita T Lawlor, Ewa Malecka-Panas, Niccola Funel and 23 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 14 institutions in 4 countries.

Daniele CampaDepartment of Biology, University of Pisa, Pisa, Italy.
Gabriele CapursoDigestive and Liver Disease Unit, S. Andrea Hospital, 'Sapienza' University of Rome, Rome, Italy.
Manuela PastoreDepartment of Biology, University of Pisa, Pisa, Italy.
Renata Talar-WojnarowskaDept of Digestive Tract Diseases, Medical University of Lodz, Poland.
Anna Caterina MilanettoDepartment of Surgery, Oncology and Gastroenterology (DISCOG), Pancreatic and Digestive Endocrine Surgery, University of Padova, Padova, Italy.
Luca LandoniDepartment of Surgery, University and Hospital Trust of Verona, Verona, Italy.
Evaristo MaielloDepartment of Oncology, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
Rita T LawlorARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.
Ewa Malecka-PanasDept of Digestive Tract Diseases, Medical University of Lodz, Poland.
Niccola FunelDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Maria GazouliDepartment of Basic Medical Sciences, Laboratory of Biology, Medical School National and Kapodistrian University of Athens, Greece.
Antonio De BonisDepartment of Surgery, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
Harald KlüterMannheim Institute of Transfusion Medicine and Immunology, Heidelberg University, Medical Faculty Mannheim, German Red Cross Blood Service Baden-Württemberg - Hessen, Mannheim, Germany.
Maria RinzivilloDigestive and Liver Disease Unit, S. Andrea Hospital, 'Sapienza' University of Rome, Rome, Italy.
Gianfranco Delle FaveDigestive and Liver Disease Unit, S. Andrea Hospital, 'Sapienza' University of Rome, Rome, Italy.
Thilo HackertDepartment of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Stefano LandiDepartment of Biology, University of Pisa, Pisa, Italy.
Peter BugertMannheim Institute of Transfusion Medicine and Immunology, Heidelberg University, Medical Faculty Mannheim, German Red Cross Blood Service Baden-Württemberg - Hessen, Mannheim, Germany.
Franco BambiBlood Transfusion Service, Azienda Ospedaliero-Universitaria Meyer, Florence, Italy.
Livia ArchibugiDigestive and Liver Disease Unit, S. Andrea Hospital, 'Sapienza' University of Rome, Rome, Italy.
Aldo ScarpaARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Christos DervenisDepartment of Surgery, Konstantopouleion General Hospital Nea Ionia, Greece.
Valbona LiçoDepartment of Surgery, Oncology and Gastroenterology (DISCOG), Pancreatic and Digestive Endocrine Surgery, University of Padova, Padova, Italy.
Sara FurlanelloDepartment of Medicine (DIMED), Laboratory Medicine, University of Padova, Padova, Italy.
Oliver StrobelDepartment of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Francesca TavanoDivision of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
Daniela BassoDepartment of Medicine (DIMED), Laboratory Medicine, University of Padova, Padova, Italy.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Claudio PasqualiDepartment of Surgery, Oncology and Gastroenterology (DISCOG), Pancreatic and Digestive Endocrine Surgery, University of Padova, Padova, Italy.
Manuel GentiluomoDepartment of Biology, University of Pisa, Pisa, Italy.
Cosmeri RizzatoDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
University of Padua · ITUniversity of Pisa · ITSapienza University of Rome · ITGerman Cancer Research Center · DECasa Sollievo della Sofferenza · ITHeidelberg University · DEMedical University of Lodz · PLUniversity Hospital Heidelberg · DEUniversity of Verona · ITAgia Olga Hospital · GRGerman Red Cross · DEIstituti di Ricovero e Cura a Carattere Scientifico · ITMeyer Children's Hospital · ITNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic neuroendocrine tumors (PNETs) are heterogeneous neoplasms which represent only 2% of all pancreatic neoplasms by incidence, but 10% by prevalence. Genetic risk factors could have an important role in the disease aetiology, however only a small number of case control studies have been performed yet. To further our knowledge, we genotyped 13 SNPs belonging to the pleiotropic CDKN2A/B gene region in 320 PNET cases and 4436 controls, the largest study on the disease so far. We observed a statistically significant association between the homozygotes for the minor allele of the rs2518719 SNP and an increased risk of developing PNET (OR

Indexed as

Germ-Line MutationPolymorphism, Single NucleotideAgedAllelesCase-Control StudiesComputational BiologyCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p18FemaleGene SilencingGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHomozygoteHumansCDKN2A protein, humanCDKN2B protein, humanCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p18

Identifiers

PMID28008994
PMCPMC5180167
OpenAlexW2561627540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.