Evidence map›Paper›PMID 28008912›Full record

Trial reportScientific reports2016

Validation of a genome-wide association study implied that SHTIN1 may involve in the pathogenesis of NSCL/P in Chinese population.

Yirui Wang, Yimin Sun, Yongqing Huang, Yongchu Pan, Aihua Yin, Bing Shi, Xuefei Du, Lan Ma, Feifei Lan, Min Jiang and 8 more

Open access · goldAbstract readClinical TrialMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Association ofGenes · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Yirui WangDepartment of Biomedical Engineering, Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China.
Yimin SunDepartment of Biomedical Engineering, Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China.
Yongqing HuangDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Ningxia Medical University, Yinchuan 750004, China.
Yongchu PanJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China.
Aihua YinMedical Genetic Center, Guangdong Women and Children Hospital, Guangzhou 511442, China.
Bing ShiThe State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
Xuefei DuDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Ningxia Medical University, Yinchuan 750004, China.
Lan MaJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China.
Feifei LanMedical Genetic Center, Guangdong Women and Children Hospital, Guangzhou 511442, China.
Min JiangGeneral Hospital of Ningxia Medical University, Yinchuan 750004, China.
Jiayu ShiDivision of Growth and Development and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lei ZhangCapitalBio Corporation, Beijing 102206, China.
Xue XiaoCapitalBio Corporation, Beijing 102206, China.
Zhongwei ZhouDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Ningxia Medical University, Yinchuan 750004, China.
Hongbing JiangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China.
Lin WangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China.
Yinxue YangDepartment of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Ningxia Medical University, Yinchuan 750004, China.
Jing ChengDepartment of Biomedical Engineering, Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China.
Nanjing Medical University · CNNingxia Medical University General Hospital · CNTsinghua University · CNGuangdong Province Women and Children Hospital · CNNingxia Medical University · CNSichuan University · CNUniversity of California, Los Angeles · US

Funding

Impact of Prenatal Alcohol Exposure on Receptor Targeting and FunctioningR03AA020101 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CALDWELL, KEVIN K. · 2010 to 2011
$148k
NIAAA NIH HHS R03 AA020101
6 · The paper itself

Abstract

Orofacial clefts are among the most common birth defects in humans worldwide. A large-scale, genome-wide association study (GWAS) in the Chinese population recently identified several genetic risk variants for nonsyndromic cleft lip with or without cleft palate (NSCL/P). We selected 16 significant SNPs from the GWAS I stage (P < 1.00E-5) that had not been replicated to validate their association with NSCL/P in 1931 NSCL/P cases and 2258 controls. Ultimately, we identified a NSCL/P susceptibility loci (rs17095681 at 10q25.3, intron of SHTN1 and 27.2 kb downstream of VAX1, P

Indexed as

Genetic LociGenome-Wide Association StudyPolymorphism, Single NucleotideAsian PeopleChinaCleft LipCleft PalateFemaleHomeodomain ProteinsHumansMaleTranscription FactorsHomeodomain ProteinsTranscription FactorsVAX1 protein, human

Identifiers

PMID28008912
PMCPMC5180092
OpenAlexW2561954373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.