ArticleBirth defects research2017
High levels of iron supplementation prevents neural tube defects in the Fpn1
Article in Birth defects research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure.WIREs mechanisms of disease · 2022Review
- Parental metal exposures as potential risk factors for spina bifida in Bangladesh.Environment international · 2021Article
- Micronutrient imbalance and common phenotypes in neural tube defects.Genesis (New York, N.Y. : 2000) · 2021Review
- Article
- Prevention of neural tube defects in Lrp2 mutant mouse embryos by folic acid supplementation.Birth defects research · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPericonception maternal nutrition and folate in particular are important factors influencing the incidence of neural tube defects (NTDs). Many but not all NTDs are prevented by folic acid supplementation and there is a pressing need for additional strategies to prevent these birth defects. Other micronutrients such as iron are potential candidates, yet a clear role for iron deficiency in contributing to NTDs is lacking. Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs.
methodsWe determined the effect of periconception iron and/or folic acid supplementation on the penetrance of NTDs in the Fpn1
resultsHigh levels of iron supplementation significantly reduced the incidence of NTDs in Fpn1
conclusionOur results demonstrate that iron supplementation can prevent NTDs and forebrain truncations in the Fpn1
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Registered trials
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