Evidence map›Paper›PMID 28008669›Full record

ArticleExperimental physiology2017

R-Type Ca

Eileen S Rodriguez-Tapia, Vinogran Naidoo, Matthew DeVries, Alberto Perez-Medina, James J Galligan

Open access · bronzeAbstract read
In one paragraph

Article in Experimental physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eileen S Rodriguez-TapiaThe Neuroscience Program, Michigan State University, East Lansing, MI, 48824, USA.
Vinogran NaidooThe Neuroscience Program, Michigan State University, East Lansing, MI, 48824, USA.
Matthew DeVriesDepartment of Pharmacology & Toxicology, Michigan State University, East Lansing, MI, 48824, USA.
Alberto Perez-MedinaDepartment of Pharmacology & Toxicology, Michigan State University, East Lansing, MI, 48824, USA.
James J GalliganThe Neuroscience Program, Michigan State University, East Lansing, MI, 48824, USA.ORCID 0000-0001-7882-5596
Michigan State University · US

Funding

PRESYNAPTIC MECHANISMS IN THE INTESTINER01DK057039 · NIDDK · MICHIGAN STATE UNIVERSITY · PI GALLIGAN, JAMES J. · 2000 to 2008
$1.8M
Purinergic neurotransmission in the gutR01DK094932 · NIDDK · MICHIGAN STATE UNIVERSITY · PI GALLIGAN, JAMES J. · 2012 to 2016
$1.5M
Presynaptic mechanisms in the intestineR56DK057039 · NIDDK · MICHIGAN STATE UNIVERSITY · PI GALLIGAN, JAMES J. · 2010 to 2010
$353k
NIDDK NIH HHS R01 DK057039NIDDK NIH HHS R01 DK094932NIDDK NIH HHS R56 DK057039
6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? Subtypes of enteric neurons are coded by the neurotransmitters they synthesize, but it is not known whether enteric neuron subtypes might also be coded by other proteins, including calcium channel subtypes controlling neurotransmitter release. What is the main finding and its importance? Our data indicate that guinea-pig ileum myenteric neuron subtypes may be coded by calcium channel subtypes. We found that R-type calcium channels are expressed by inhibitory but not excitatory longitudinal muscle motoneurons. R-Type calcium channels are also not expressed by circular muscle inhibitory motoneurons. Calcium channel subtype-selective antagonists could be used to target subtypes of neurons to treat gastrointestinal motility disorders. There is evidence that R-type Ca

Indexed as

AcetylcholineAnimalsApaminArginineCadmium ChlorideCalcium Channels, R-TypeGuinea PigsIleumMaleMotor NeuronsMuscle, SmoothMyenteric PlexusNeurotransmitter AgentsNitric Oxide SynthaseNitroarginineSynaptic TransmissionAcetylcholineApaminArginineCadmium ChlorideCalcium Channels, R-TypeNeurotransmitter AgentsNitric Oxide SynthaseNitroargininecalcium channelnitric oxidepurinergic signalingsynaptic transmission

Identifiers

PMID28008669
PMCPMC5332280
OpenAlexW2561134288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.