ReviewNagoya journal of medical science2016
Central diabetes insipidus.
Review in Nagoya journal of medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The Time of the Hypertonic Saline Infusion Test for the Diagnosis of AVP Deficiency Can Be Shortened With LC-MS/MS.The Journal of clinical endocrinology and metabolism · 2026Trial
- Machine learning-based prediction of impaired arginine vasopressin secretion during hypertonic saline test.Endocrine journal · 2026Article
- Central Diabetes Insipidus and Brain Herniation Secondary to Cryptococcal Meningitis in a Dog.Clinical case reports · 2026Article
- Article
- Phagophores originate from endoplasmic reticulum membranes in vasopressin neurons in a mouse model of familial neurohypophysial diabetes insipidus.Cell and tissue research · 2025Article
- Article
- Diabetes insipidus as a presentation of lung adenocarcinoma: a case report.Journal of medical case reports · 2025Article
- Intraoperative Transient Central Diabetes Insipidus Status Post-Cerebellopontine Meningioma Resection: A Case Report.Cureus · 2024Article
- Antidiuretic hormone deficiency secondary to inactive hydrocephalus: a case report.Journal of medical case reports · 2024Article
- Deficiency of arginine vasopressin in children - diagnostic and therapeutic approaches to improve patients' quality of life based on a 25-year, single-centre retrospective analysis.Pediatric endocrinology, diabetes, and metabolism · 2024Article
- Article
- Central Diabetes Insipidus in the Background of Lithium Use: Consider Central Causes Despite Nephrogenic as the Most Common.The American journal of case reports · 2023Article
- Exploring the diversity of AVPR2 in Primates and its evolutionary implications.Genetics and molecular biology · 2023Article
- Serum copeptin levels at day two after pituitary surgery and ratio to baseline predict postoperative central diabetes insipidus.Pituitary · 2022Observational
- Idiopathic central diabetes insipidus in a large cohort of patients: the hypopituitarism ENEA rare observational (HEROS) study.Pituitary · 2022Observational
- Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state.Scientific reports · 2022Article
- Ketoacidosis, Hypertriglyceridemia and Acute Pancreatitis Induced by Soft Drink Polydipsia in a Patient with Occult Central Diabetes Insipidus.Internal medicine (Tokyo, Japan) · 2022Article
- Functional analyses of three different mutations in the AVP-NPII gene causing familial neurohypophyseal diabetes insipidus.Endocrine · 2021Article
- Deficiency of WFS1 leads to the impairment of AVP secretion under dehydration in male mice.Pituitary · 2021Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous study suggests that infundibulo-neurohypophysitis might be an underlying cause of idiopathic CDI. Among secondary CDI, the tumors in the central nervous system such as craniopharyngioma and germ cell tumors are the most frequent causes. Familial CDI is inherited mostly in an autosomal dominant mode, and the number of causal mutations in the AVP gene locus reported so far exceeds 80. CDI is treated with desmopressin, an analogue of vasopressin, and the tablet is preferred to the nasal form because it is easier to administer. It is also shown that the oral disintegrating tablet formula increases QOL and decreases the incidence of hyponatremia in CDI patients. In some CDI patients, the osmoreceptors in the hypothalamus do not function and patients do not sense thirst. These adipsic CDI patients are treated with desmopressin and adjusting the amount of daily water intake based on body weight measurement; but controlling the water balance is extremely difficult, and morbidity and mortality are shown to be high in these patients.
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