ArticleInternational journal of obesity (2005)2017
Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- Mitochondrial uncoupling, energy substrate utilization, and brown adipose tissue as therapeutic targets in cancer.npj metabolic health and disease · 2025Review
- Molecular mechanisms of UCP1-independent thermogenesis: the role of futile cycles in energy dissipation.Journal of physiology and biochemistry · 2025Review
- Cold exposure stimulates cross-tissue metabolic rewiring to fuel glucose-dependent thermogenesis in brown adipose tissue.Science advances · 2025Article
- Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity.Physiological research · 2024Review
- Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.Molecular metabolism · 2022Article
- Cold exposure prevents fat accumulation in striped hamsters refed a high-fat diet following food restriction.BMC zoology · 2022Article
- Lipid Droplets: A Cellular Organelle Vital for Thermogenesis.International journal of biological sciences · 2022Review
- Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men.Cell reports. Medicine · 2021Article
- The cellular and functional complexity of thermogenic fat.Nature reviews. Molecular cell biology · 2021Review
- Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics.Nature reviews. Endocrinology · 2021Review
- Mitochondrial Lipid Signaling and Adaptive Thermogenesis.Metabolites · 2021Review
- Article
- Downregulation of theAntioxidants (Basel, Switzerland) · 2020Article
- Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice.Diabetes · 2020Article
- Postnatal induction of muscle fatty acid oxidation in mice differing in propensity to obesity: a role of pyruvate dehydrogenase.International journal of obesity (2005) · 2020Article
- Redox control of non-shivering thermogenesis.Molecular metabolism · 2019Review
- Rosiglitazone remodels the lipid droplet and britens human visceral and subcutaneous adipocytes ex vivo.Journal of lipid research · 2019Article
- Reduced Number of Adipose Lineage and Endothelial Cells in Epididymal fat in Response to Omega-3 PUFA in Mice Fed High-Fat Diet.Marine drugs · 2018Article
- Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation.Journal of lipid research · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveFutile substrate cycling based on lipolytic release of fatty acids (FA) from intracellular triacylglycerols (TAG) and their re-esterification (TAG/FA cycling), as well as de novo FA synthesis (de novo lipogenesis (DNL)), represent the core energy-consuming biochemical activities of white adipose tissue (WAT). We aimed to characterize their roles in cold-induced thermogenesis and energy homeostasis.
methodsMale obesity-resistant A/J and obesity-prone C57BL/6J mice maintained at 30 °C were exposed to 6 °C for 2 or 7 days. In epididymal WAT (eWAT), TAG synthesis and DNL were determined using in vivo
resultsThe mass of WAT depots declined during cold exposure (CE). Plasma levels of TAG and non-esterified FA were decreased by day 2 but tended to normalize by day 7 of CE. TAG synthesis (reflecting TAG/FA cycle activity) gradually increased during CE. DNL decreased by day 2 of CE but increased several fold over the control values by day 7. Expression of genes involved in lipolysis, glyceroneogenesis, FA re-esterification, FA oxidation and mitochondrial biogenesis in eWAT was induced during CE. All these changes were more pronounced in obesity-resistant A/J than in B6 mice and occurred in the absence of uncoupling protein 1 in eWAT. Expression of markers of glyceroneogenesis in eWAT correlated negatively with hepatic FA synthesis by day 7 in both strains. Leptin and fibroblast growth factor 21 plasma levels were differentially affected by CE in the two mouse strains.
conclusionsOur results indicate integrated involvement of (i) TAG/FA cycling and DNL in WAT, and (ii) hepatic very-low-density lipoprotein-TAG synthesis in the control of blood lipid levels and provision of FA fuels for thermogenesis in cold. They suggest that lipogenesis in WAT contributes to a lean phenotype.
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