ArticleOncotarget2017
Outcomes of surgery for gastric cancer with distant metastases: a retrospective study from the SEER database.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
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- Hospital variation in treatment for synchronous metastatic esophageal and gastric cancer: A nationwide population-based study in the Netherlands.International journal of cancer · 2025Article
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- Surgery Matters: Progress in Surgical Management of Gastric Cancer.Current treatment options in oncology · 2023Review
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- Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis.Journal of translational medicine · 2022Article
- Multimodal treatment in oligometastatic gastric cancer.World journal of gastrointestinal oncology · 2022Review
- SURGICAL TREATMENT IN CLINICAL STAGE IV GASTRIC CANCER: A COMPARISON OF DIFFERENT PROCEDURES AND SURVIVAL OUTCOMES.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022Article
- Time-extended exposure of gastric epithelial cells to secretome ofAmerican journal of cancer research · 2022Article
- Role of locoregional surgery in treating FIGO 2009 stage IVB cervical cancer patients: a population-based study.BMJ open · 2021Article
- Perioperative FLOT chemotherapy plus surgery for oligometastatic esophagogastric adenocarcinoma: surgical outcome and overall survival.BMC surgery · 2021Article
- Primary tumor resection benefited the survival of patients with distant metastatic gastric cancer.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Enhancing the chemotherapy effect of Apatinib on gastric cancer by co-treating with salidroside to reprogram the tumor hypoxia micro-environment and induce cell apoptosis.Drug delivery · 2020Article
- Long-TermMicroorganisms · 2020Article
- Exploring TCGA database for identification of potential prognostic genes in stomach adenocarcinoma.Cancer cell international · 2020Article
- The survival benefit of palliative gastrectomy and/or metastasectomy in gastric cancer patients with synchronous metastasis: a population-based study using propensity score matching and coarsened exact matching.Journal of Cancer · 2019Article
- Role of Helicobacter pylori infection in cancer-associated fibroblast-induced epithelial-mesenchymal transition in vitro.Helicobacter · 2018Article
- Oligometastatic Disease in Upper Gastrointestinal Cancer - How to Proceed?Visceral medicine · 2017Review
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of surgical therapy in gastric cancer patients with distant metastases remains controversial. This retrospective analysis was performed to identify whether gastric cancer patients with distant metastases might benefit from surgery. PATIENTS AND
methodsA total of 5185 patients from the SEER database who were initially diagnosed with histologically confirmed gastric cancer with distant metastases from 2004 to 2009 were included. Patients were divided into the following three groups: patients who underwent resection of both the primary tumor and distant metastatic tumors ('PMTR' group), patients who only underwent resection of the primary tumor ('PTR' group) and patients who did not undergo any surgery ('No surgery' group). We employed the Kaplan-Meier analysis, the log-rank test and multivariate Cox proportional hazards regression models to estimate the survival time of the different groups.
resultsA total of 5185 patients had a median survival time (MST) of 9.0 months. The improvement in survival of the 'PMTR' and 'PTR' groups was significantly different compared with that of the 'No surgery' group (MST, 12.0 vs 12.0 vs 9.0 months, respectively, P<0.001; 1-year survival rate, 49.6% vs 49.1% vs 30.1%, respectively, P<0.001; 3-year survival rate, 12.5% vs 15.1% vs 5.8%, respectively, P<0.001), whereas no significant difference was found between the 'PMTR' group and 'PTR' group (P=0.642). Multivariate Cox proportional analysis showed that surgery was an independent prognostic factor ('PMTR', hazard ratio (HR) =0.648, 95% confidence interval (CI) 0.574-0.733, P<0.001; 'PTR', HR=0.631, 95% CI 0.583-0.684, P<0.001).
conclusionsThis retrospective analysis demonstrated that combined PTR and metastasectomy or PTR alone were independent prognostic factors for survival improvement in gastric cancer patients with distant metastases. Because no statistically significant difference in survival was observed between the 'PMTR' group and 'PTR' group, PTR, which is a more minor surgery, might be more appropriate than PMTR in clinical practice for gastric cancer patients with distant metastases.
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