ArticleSocial cognitive and affective neuroscience2017
Anxious anticipation and pain: the influence of instructed vs conditioned threat on pain.
Article in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial.Nutrients · 2022Trial
- Widespread Pressure Delivered by a Weighted Blanket Reduces Chronic Pain: A Randomized Controlled Trial.The journal of pain · 2022Trial
- Influence of pain anticipation on brain activity and pain perception in Gulf War Veterans with chronic musculoskeletal pain.Psychophysiology · 2019Trial
- Brain activations associated with fearful experience show common and distinct patterns between younger and older adults in the hippocampus and the amygdala.Scientific reports · 2018Trial
- Pain Expectation in Individuals With High Autistic Traits: Decision-Evaluation Processes and Oxytocin Modulation.Annals of the New York Academy of Sciences · 2026Article
- A neural signature for the subjective experience of threat anticipation under uncertainty.Nature communications · 2024Article
- Enhancing the comfort of hospitalized elderly patients: pain management strategies for painful nursing procedures.Frontiers in medicine · 2024Article
- Article
- Prolonged duration of epidural labour analgesia decreases the success rate of epidural anaesthesia for caesarean section.Annals of medicine · 2022Article
- [Prolonged epidural labor analgesia increases risks of epidural analgesia failure for conversion to cesarean section].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Altered metabolic connectivity between the amygdala and default mode network is related to pain perception in patients with cancer.Scientific reports · 2022Article
- Disempowering women-a mixed methods study exploring informational support about pain persisting after childbirth and its consequences.BMC pregnancy and childbirth · 2022Article
- Characterization of whole-brain task-modulated functional connectivity in response to nociceptive pain: A multisensory comparison study.Human brain mapping · 2022Article
- Attention Control and Audiomotor Processes Underlying Anticipation of Musical Themes while Listening to Familiar Sonata-Form Pieces.Brain sciences · 2022Article
- Altered Brain Topological Property Associated With Anxiety in Experimental Orthodontic Pain.Frontiers in neuroscience · 2022Article
- The influence of a manipulation of threat on experimentally-induced secondary hyperalgesia.PeerJ · 2022Article
- Psychomotor Predictive Processing.Entropy (Basel, Switzerland) · 2021Article
- Assessing the role of the amygdala in fear of pain: Neural activation under threat of shock.Journal of affective disorders · 2020Article
- Pavlov's Pain: the Effect of Classical Conditioning on Pain Perception and its Clinical Implications.Current pain and headache reports · 2019Review
- Structural Co-Variance Patterns in Migraine: A Cross-Sectional Study Exploring the Role of the Hippocampus.Headache · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Negative emotions such as anxiety enhance pain perception. However, certain threat characteristics are discussed to have different or even divergent effects on pain (hypoalgesia vs hyperalgesia). In order to investigate the neurobiological basis of different threats, we compared the impact of conditioned threat (CT) vs instructed threat (IT) on pain using fMRI. In two groups, participants underwent either Pavlovian threat conditioning or an instructed threat procedure. Afterwards, in an identical test phase participants watched the same visual cues from the previous phase indicating potential threat or safety, and received painful thermal stimulation. In the test phase, pain ratings were increased in both groups under threat. Group comparisons show elevated responses in amygdala and hippocampus for pain under threat in the CT group, and higher activation of the mid-cingulate gyrus (MCC) in the IT group. Psychophysiological interaction analyses in CT demonstrated elevated connectivity of the amygdala and the insula for the comparison of pain under threat vs safety. In IT, the same comparison revealed elevated functional connectivity of the MCC and the insula. The results suggest a similar pain augmenting effect of CT and IT, which, however, seems to rely on different networks mediating the impact of threat on pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.