ArticleMolecular biology and evolution2017
Archaic Adaptive Introgression in TBX15/WARS2.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 119 citations in OpenAlex.
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- A global map for introgressed structural variation and selection in humans.Science (New York, N.Y.) · 2026Article
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Genetic insights into the peoples who shaped the American continent.Genetics and molecular biology · 2026Article
- Global impact of micronutrients in modern human evolution.American journal of human genetics · 2025Article
- Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergence.bioRxiv : the preprint server for biology · 2025Article
- TheScience (New York, N.Y.) · 2025Article
- Neanderthal adaptive introgression shapedProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A refined analysis of Neanderthal-introgressed sequences in modern humans with a complete reference genome.Genome biology · 2025Article
- Human dispersal into East Eurasia: ancient genome insights and the need for research on physiological adaptations.Journal of physiological anthropology · 2025Review
- PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans.Current biology : CB · 2025Article
- A history of multiple Denisovan introgression events in modern humans.Nature genetics · 2024Review
- Ethnic differences in CT derived abdominal body composition measures: a comparative retrospect pilot study between European and Inuit study population.International journal of circumpolar health · 2024Article
- Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations.Journal of physiological anthropology · 2024Article
- Denisovan admixture facilitated environmental adaptation in Papua New Guinean populations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Biogeographic Perspectives on Human Genetic Diversification.Molecular biology and evolution · 2024Article
- More than a decade of genetic research on the Denisovans.Nature reviews. Genetics · 2024Review
- The genetics of adipose tissue metabolism.Royal Society open science · 2024Article
- Archaic Introgression Shaped Human Circadian Traits.Genome biology and evolution · 2023Article
- Inferring multi-locus selection in admixed populations.PLoS genetics · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using single nucleotide polymorphism chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome, and was likely introgressed from an archaic population. The region contains two genes, WARS2 and TBX15, and has previously been associated with adipose tissue differentiation and body-fat distribution in humans. We show that the adaptively introgressed allele has been under selection in a much larger geographic region than just Greenland. Furthermore, it is associated with changes in expression of WARS2 and TBX15 in multiple tissues including the adrenal gland and subcutaneous adipose tissue, and with regional DNA methylation changes in TBX15.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.