Evidence map›Paper›PMID 28007961›Full record

ArticleThe Journal of biological chemistry2017

c-JUN Dimerization Protein 2 (JDP2) Is a Transcriptional Repressor of Follicle-stimulating Hormone β (FSHβ) and Is Required for Preventing Premature Reproductive Senescence in Female Mice.

Carrie R Jonak, Nancy M Lainez, Lacey L Roybal, Alexa D Williamson, Djurdjica Coss

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  11. ILC Differentiation in the Thymus.Advances in experimental medicine and biology · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. PACAP induces FSHβ gene expression via EPAC.Molecular and cellular endocrinology · 2019
    Article
  16. Article
  17. GnRH-A Key Regulator of FSH.Endocrinology · 2019
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Carrie R JonakFrom the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521.
Nancy M LainezFrom the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521.
Lacey L RoybalFrom the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521.
Alexa D WilliamsonFrom the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521.
Djurdjica CossFrom the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521 djurdjica.coss@ucr.edu.
University of California, Riverside · US

Funding

PROJECT 3 - Steroid-Metabolic Interactions In the Control of GnRH NeuronsU54HD028934 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI SHUPNIK, MARGARET A · 1998 to 2013
$16.5M
The Role of AP-1 in the GonadotropeR01HD057549 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COSS, DJURDJICA · 2009 to 2013
$1.6M
NICHD NIH HHS R01 HD057549NICHD NIH HHS U54 HD028934
6 · The paper itself

Abstract

Follicle-stimulating hormone (FSH) regulates follicular growth and stimulates estrogen synthesis in the ovaries. FSH is a heterodimer consisting of an α subunit, also present in luteinizing hormone, and a unique β subunit, which is transcriptionally regulated by gonadotropin-releasing hormone 1 (GNRH). Because most FSH is constitutively secreted, tight transcriptional regulation is critical for maintaining FSH levels within a narrow physiological range. Previously, we reported that GNRH induces FSHβ (

Indexed as

AnimalsFemaleFollicle Stimulating HormoneGonadotropin-Releasing HormoneMiceMice, KnockoutPrimary Ovarian InsufficiencyPromoter Regions, GeneticRepressor ProteinsFollicle Stimulating HormoneGonadotropin-Releasing HormoneJundp2 protein, mouseRepressor ProteinsAP-1 transcription factor (AP-1)c-FOSc-JUN transcription factorendocrinologyfollicle-stimulating hormone (FSH)gene expressiongene transcription

Identifiers

PMID28007961
PMCPMC5314163
OpenAlexW2564300643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.