Evidence map›Paper›PMID 28007959›Full record

ArticleThe Journal of biological chemistry2017

RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis.

Sajad Mir, Weikang Cai, Douglas A Andres

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Maternal low-sodium diet impairs hippocampal neurogenesis and cognition in adult mouse offspring.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  2. Article
  3. Article
  4. The Oil Formulation Derived fromJournal of experimental pharmacology · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. The potential oncogenic role of the RAS-like GTP-binding gene RIT1 in glioblastoma.Cancer biomarkers : section A of Disease markers · 2020
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sajad MirFrom the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0509 and.
Weikang CaiFrom the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0509 and.
Douglas A AndresFrom the Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0509 and dandres@uky.edu.
University of Kentucky · USJoslin Diabetes Center · US

Funding

Regulation of Neuronal Survival by the Rit GTPaseR01NS045103 · NINDS · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN · 2003 to 2012
$2.7M
NINDS NIH HHS R01 NS045103
6 · The paper itself

Abstract

Adult neurogenesis, the process of generating mature neurons from neuronal progenitor cells, makes critical contributions to neural circuitry and brain function in both healthy and disease states. Neurogenesis is a highly regulated process in which diverse environmental and physiological stimuli are relayed to resident neural stem cell populations to control the transcription of genes involved in self-renewal and differentiation. Understanding the molecular mechanisms governing neurogenesis is necessary for the development of translational strategies to harness this process for neuronal repair. Here we report that the Ras-related GTPase RIT1 serves to control the sequential proliferation and differentiation of adult hippocampal neural progenitor cells, with

Indexed as

NeurogenesisTranscription, GeneticAnimalsHippocampusMiceMice, TransgenicProto-Oncogene Proteins c-aktras ProteinsSignal TransductionSOXB1 Transcription FactorsProto-Oncogene Proteins c-aktras ProteinsRit1 protein, mouseSox2 protein, mouseSOXB1 Transcription FactorsAktdentate gyrusGTPasehippocampusneurogenesisneuronPKBRas proteinRIT1Sox2

Identifiers

PMID28007959
PMCPMC5313081
OpenAlexW2562909144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.