ArticleMolecular systems biology2016
Frequency doubling in the cyanobacterial circadian clock.
Article in Molecular systems biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Cyanobacterial Circadian Clock: Molecular Mechanisms and Physiological Outputs.Plants (Basel, Switzerland) · 2026Review
- Sinusoidal regulation reduces circadian period variability.Scientific reports · 2025Article
- Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Environmental and molecular noise buffering by the cyanobacterial clock in individual cells.Nature communications · 2025Article
- Leaf starch metabolism sets the phase of stomatal rhythm.The Plant cell · 2023Article
- Article
- Decomposing biophotovoltaic current density profiles using the Hilbert-Huang transform reveals influences of circadian clock on cyanobacteria exoelectrogenesis.Scientific reports · 2022Article
- Thermodynamics contributes to high limonene productivity in cyanobacteria.Metabolic engineering communications · 2022Article
- Review
- Circadian misalignment on submarines and other non-24-h environments - from research to application.Military Medical Research · 2020Review
- An intrinsic oscillator drives the blood stage cycle of the malaria parasiteScience (New York, N.Y.) · 2020Article
- A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics.International journal of molecular sciences · 2019Article
- Cell size control driven by the circadian clock and environment in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- An incoherent feed-forward loop switches the Arabidopsis clock rapidly between two hysteretic states.Scientific reports · 2018Article
- Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes.Frontiers in physiology · 2018Article
- Statistics and simulation of growth of single bacterial cells: illustrations with B. subtilis and E. coli.Scientific reports · 2017Article
- A novel interaction perturbation analysis reveals a comprehensive regulatory principle underlying various biochemical oscillators.BMC systems biology · 2017Article
- Frequency doubling in the cyanobacterial circadian clock.Molecular systems biology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Organisms use circadian clocks to generate 24-h rhythms in gene expression. However, the clock can interact with other pathways to generate shorter period oscillations. It remains unclear how these different frequencies are generated. Here, we examine this problem by studying the coupling of the clock to the alternative sigma factor sigC in the cyanobacterium Synechococcus elongatus Using single-cell microscopy, we find that psbAI, a key photosynthesis gene regulated by both sigC and the clock, is activated with two peaks of gene expression every circadian cycle under constant low light. This two-peak oscillation is dependent on sigC, without which psbAI rhythms revert to one oscillatory peak per day. We also observe two circadian peaks of elongation rate, which are dependent on sigC, suggesting a role for the frequency doubling in modulating growth. We propose that the two-peak rhythm in psbAI expression is generated by an incoherent feedforward loop between the clock, sigC and psbAI Modelling and experiments suggest that this could be a general network motif to allow frequency doubling of outputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.