ArticleGenetics2017
Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex.
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- The Late Boundary Complex (LBC) Selectively Binds the Fab-7/Fab-8 Boundaries, but not Fab-6 or Mcp, in the Abd-B Regulatory Region of Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2026Article
- Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023Review
- Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain.PLoS genetics · 2022Article
- Overlapping but Distinct Sequences Play Roles in the Insulator and Promoter Activities of theGenetics · 2020Article
- The insulator functions of theScience advances · 2020Article
- Article
- Complete reconstitution of bypass and blocking functions in a minimal artificialProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Boundaries mediate long-distance interactions between enhancers and promoters in the Drosophila Bithorax complex.PLoS genetics · 2018Article
- The BEN Domain Protein Insensitive Binds to theGenetics · 2018Article
- The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.PLoS genetics · 2018Article
- Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex.Molecular and cellular biology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Chromatin boundary elements subdivide chromosomes in multicellular organisms into physically independent domains. In addition to this architectural function, these elements also play a critical role in gene regulation. Here we investigated the evolution of a Drosophila Bithorax complex boundary element called Fab-7, which is required for the proper parasegment specific expression of the homeotic Abd-B gene. Using a "gene" replacement strategy, we show that Fab-7 boundaries from two closely related species, D. erecta and D. yakuba, and a more distant species, D. pseudoobscura, are able to substitute for the melanogaster boundary. Consistent with this functional conservation, the two known Fab-7 boundary factors, Elba and LBC, have recognition sequences in the boundaries from all species. However, the strategies used for maintaining binding and function in the face of sequence divergence is different. The first is conventional, and depends upon conservation of the 8 bp Elba recognition sequence. The second is unconventional, and takes advantage of the unusually large and flexible sequence recognition properties of the LBC boundary factor, and the deployment of multiple LBC recognition elements in each boundary. In the former case, binding is lost when the recognition sequence is altered. In the latter case, sequence divergence is accompanied by changes in the number, relative affinity, and location of the LBC recognition elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.