ReviewInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2017
Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia.
Review in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02715271 (Study of TB Lesions Obtained in Surgery), which is not on this map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of TB Lesions Obtained in Surgery: in Search of Best Biomarkers Correlating With TB Pathology, Clinical Features, MDR Cases and Prognostic
Who cites it
10 citing papers in PubMed.
- Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications.Nature communications · 2025Article
- Intercellular mosaic methylation in fast-growingNAR molecular medicine · 2024Article
- The Trend, Characteristics and Treatment Outcomes in Patients with Tuberculosis Undergoing Thoracic Surgery in the Kyrgyz Republic between 2017 and 2021.Tropical medicine and infectious disease · 2023Article
- Review
- Characteristics and Treatment Outcomes of Patients with Tuberculosis Receiving Adjunctive Surgery in Uzbekistan.International journal of environmental research and public health · 2021Article
- Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections.Nature communications · 2021Observational
- Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.Nature communications · 2020Article
- Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils.Mucosal immunology · 2020Article
- Impact of adjuvant therapeutic surgery on the health-related quality of life of pulmonary tuberculosis patients.ERJ open research · 2020Article
- Current Indications and Outcome of Pulmonary Resections for Tuberculosis Complications in Ibadan, Nigeria.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesOur aim was to retrospectively compare clinical data and characteristics of removed lesions of the cohort of patients undergoing therapeutical surgery for their tuberculosis. DESIGN AND
methodsDemographic and epidemiological details, clinical data, data on the surgery performed, macroscopic characteristics of the TB lesions removed, and outcome were recorded retrospectively from the 137 patients who underwent therapeutical surgery for their TB in Tbilisi, Georgia during 2014 and 2015.
resultsMen represented 70% of the included patients, presented more comorbidities and underwent operation earlier in terms of days between diagnostic and surgery. Women underwent operation at younger ages, and in MDR/XDR-TB cases, showed higher percentages of sputum conversion at >2 months and of fresh necrosis in the surgical specimens, suggesting a worse evolution. Half of cases were MDR/XDR-TB cases. In spite of being considered microbiologically cured according to WHO, a non despricable percentage of cases showed viable bacilli in the surgical specimen. Even if no causality could be statistically demonstrated, differences could be encountered according to gender and drug susceptibility of the responsible strains.
conclusionsAccording to our results, host factors such as gender, type of necrosis found in the lesions, size of lesions and presence of viable bacilli in the surgical specimen, should be included in future studies on therapeutical surgery of TB. As most of studies are done in MDR/XDR-TB, more data on DS-TB operated cases are needed. Our results also highlight that, in spite of achieving the microbiologically cured status, sterilization might not occur, and thus new biomarkers and new methods to evaluate the healing process of TB patients are urgently needed and radiological assays should be taken into account.
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