ArticleToxicology letters2017
Reproductive toxicity of linuron following gestational exposure in rats and underlying mechanisms.
Article in Toxicology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Endocrine Disruptive Effects of the Herbicides Linuron, Chloridazon and Metribuzin on Bovine Granulosa Cells.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Insights into cytotoxicity and redox modulation by the herbicide linuron and its metabolite, 3,4-dichloroaniline.Neurotoxicology · 2025Article
- Scientific and Regulatory Perspectives on Chemical Risk Assessment of Pesticides in the European Union.Journal of xenobiotics · 2025Review
- ZIF-8 as Potential Pesticide Adsorbent Medium for Wastewater Treatment: The Case Study of Model Linuron Extraction Conditions Optimization via Design of Experiment.Molecules (Basel, Switzerland) · 2025Article
- Prenatal linuron exposure disrupts adrenal steroidogenesis and induces adrenal insufficiency in male rat offspring.Current research in toxicology · 2025Article
- Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies.Journal of health & pollution · 2024Review
- Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Herbicides widely used in the world: an investigation of toxic effects on Caenorhabditis elegans.Biologia futura · 2023Article
- QuantitativeEnvironmental health perspectives · 2020Article
- α-lipoic acid protects testis and epididymis against linuron-induced oxidative toxicity in adult rats.Toxicological research · 2020Article
- Maternal linuron exposure alters testicular development in male offspring rats at the whole genome level.Toxicology · 2017Article
- Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids.PPAR research · 2017Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Linuron is a widely used herbicide in agriculture; its endocrine disruptive toxicity has recently received public attention. This study was designed to examine the developmental toxicity of linuron on the reproductive system of male offspring following maternal exposure. Mother rats received oral gavages of linuron, once daily, at the dose of 0, 50, 100, 150 or 200mg/kg, from gestational day (GD)13 to GD18; gonadal organs from GD20 fetuses were examined. Data indicated that exposed male offspring had a significantly shortened anogenital distance. Pathological examination further revealed a lack of fusion in the urogenital fold in treated fetuses, the damaged seminiferous tubules, and the injured Leydig cell ultrastructure. Analysis of serum testosterone concentrations at postnatal day (PND)2 showed a significant dose-related reduction (about 33.7-58.75%, r=-0.838, p<0.05) as compared to controls. Immunohistochemical results demonstrated a significantly reduced expression of enzymes pertinent to the testosterone production including P450scc, 3β-HSD, and PCNA in Leydig cells (p<0.05). qPCR studies confirmed decreased levels of mRNAs encoding P450scc, 3β-HSD and PCNA (p<0.05). Taken together, these data suggest that maternal exposure to linuron hampers the male gonadal organ development; this appears to be due to linuron's direct action on the production of testosterone in fetal and postnatal offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.