Evidence map›Paper›PMID 28007622›Full record

ReviewChest2017

Control of Ventilation in Health and Disease.

Susmita Chowdhuri, M Safwan Badr

Open access · greenAbstract readReview
In one paragraph

Review in Chest, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Virulence · 2022
    Pooled it
  2. Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Evaluation of clinical and genetic factors in obstructive sleep apnoea.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023
    Article
  12. Review
  13. Relationship between Sleep and Hypertension: Findings from the NHANES (2007-2014).International journal of environmental research and public health · 2021
    Article
  14. Will Intranasal Leptin Mitigate Opioid-induced Sleep-disordered Breathing?American journal of respiratory cell and molecular biology · 2020
    Article
  15. Aging is associated with increased propensity for central apnea during NREM sleep.Journal of applied physiology (Bethesda, Md. : 1985) · 2018
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Susmita ChowdhuriJohn D. Dingell VA Medical Center, Wayne State University, Detroit MI; Department of Medicine, Wayne State University, Detroit MI. Electronic address: schowdh@med.wayne.edu.
M Safwan BadrJohn D. Dingell VA Medical Center, Wayne State University, Detroit MI; Department of Medicine, Wayne State University, Detroit MI.
John D. Dingell VA Medical Center · USWayne State University · US

Funding

CENTRAL SLEEP APNEA--ROLE OF LONGTERM FACILITATIONR01HL053443 · NHLBI · WAYNE STATE UNIVERSITY · PI BADR, M.SAFWAN · 1999 to 2009
$1.8M
Sleep-Disordered Breathing in patients with C-SCI: Mechanisms and TherapyR01HL130552 · NHLBI · WAYNE STATE UNIVERSITY · PI BADR, M.SAFWAN · 2016 to 2020
$1.5M
CSRD VA I01 CX000194NHLBI NIH HHS R01 HL053443NHLBI NIH HHS R01 HL130552
6 · The paper itself

Abstract

Control of ventilation occurs at different levels of the respiratory system through a negative feedback system that allows precise regulation of levels of arterial carbon dioxide and oxygen. Mechanisms for ventilatory instability leading to sleep-disordered breathing include changes in the genesis of respiratory rhythm and chemoresponsiveness to hypoxia and hypercapnia, cerebrovascular reactivity, abnormal chest wall and airway reflexes, and sleep state oscillations. One can potentially stabilize breathing during sleep and treat sleep-disordered breathing by identifying one or more of these pathophysiological mechanisms. This review describes the current concepts in ventilatory control that pertain to breathing instability during wakefulness and sleep, delineates potential avenues for alternative therapies to stabilize breathing during sleep, and proposes recommendations for future research.

Indexed as

HumansHypercapniaHypoxiaPulmonary VentilationSleep Apnea SyndromesWakefulness

Identifiers

PMID28007622
PMCPMC8894312
OpenAlexW2561602825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.