Evidence map›Paper›PMID 28007400›Full record

ArticleNeurotoxicology2017

Consequences of acute Na

T F James, Miroslav N Nenov, Cynthia M Tapia, Marzia Lecchi, Shyny Koshy, Thomas A Green, Fernanda Laezza

Abstract read
In one paragraph

Article in Neurotoxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. mTORC2-NaChannels (Austin, Tex.) · 2026
    Article
  2. Article
  3. Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Voltage-Gated NaLife (Basel, Switzerland) · 2023
    Review
  6. Characterization in Potent Modulation on Voltage-Gated NaInternational journal of molecular sciences · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Review:Frontiers in genetics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

T F JamesDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, USA; Neuroscience Graduate Program, University of Texas Medical Branch, USA.
Miroslav N NenovDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, USA.
Cynthia M TapiaDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, USA.
Marzia LecchiDepartment of Biotechnology and Bioscience, University of Milano-Bicocca, Italy.
Shyny KoshyDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, USA; Center for Addiction Research, University of Texas Medical Branch, USA.
Thomas A GreenDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, USA; Center for Addiction Research, University of Texas Medical Branch, USA.
Fernanda LaezzaDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, USA; Mitchell Center for Neurodegenerative Diseases, USA; Center for Environmental Toxicology, University of Texas Medical Branch, USA; Center for Addiction Research, University of Texas Medical Branch, USA. Electronic address: felaezza@utmb.edu.
The University of Texas Medical Branch at Galveston · USInstitute for Neurodegenerative Disorders · USUniversity of Milano-Bicocca · IT

Funding

Synthetic Organic Chemistry CoreP30ES006676 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 1995 to 2017
$21.7M
Molecular Mechanisms of Environmental InjuryT32ES007254 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AMEREDES, BILL T · 1990 to 2022
$6.6M
Validation of FGF14 as a New Molecular Target of GSK3R01MH095995 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2012 to 2016
$1.9M
NIEHS NIH HHS P30 ES006676NIEHS NIH HHS T32 ES007254NIMH NIH HHS R01 MH095995
6 · The paper itself

Abstract

backgroundPyrethroid insecticides are the most popular class of insecticides in the world, despite their near-ubiquity, their effects of delaying the onset of inactivation of voltage-gated sodium (Na

objectiveHere we compare the well-studied Na

methodsWe used patch-clamp electrophysiology to record sodium currents encoded by either Na

resultsWe found that exposure of both isoforms to 10μM deltamethrin significantly potentiated persistent and tail current densities without affecting peak transient current densities, and only Na

conclusionCollectively, these data provide evidence that Na GENERAL SIGNIFICANCE: These findings identify Na

Indexed as

HEK293 CellsHumansInsecticidesMembrane PotentialsNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelNitrilesProtein IsoformsPyrethrinsdecamethrinInsecticidesNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelNitrilesProtein IsoformsPyrethrinsSCN1A protein, humanSCN8A protein, human

Identifiers

PMID28007400
PMCPMC5447465
OpenAlexW2562357591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.