Evidence map›Paper›PMID 28007022›Full record

ArticleCardiovascular diabetology2016

Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis.

Morgane Evin, Kathryn M Broadhouse, Fraser M Callaghan, Rachel T McGrath, Sarah Glastras, Rebecca Kozor, Samantha L Hocking, Jérôme Lamy, Alban Redheuil, Nadjia Kachenoura and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 36 citations in OpenAlex.

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  7. Atrial fibrillation substrate and impaired left atrial function: a cardiac MRI study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Morgane EvinSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Kathryn M BroadhouseSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Fraser M CallaghanSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Rachel T McGrathDepartment of Endocrinology, Royal North Shore Hospital, St Leonards, Australia.
Sarah GlastrasDepartment of Endocrinology, Royal North Shore Hospital, St Leonards, Australia.
Rebecca KozorSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Samantha L HockingDepartment of Endocrinology, Royal North Shore Hospital, St Leonards, Australia.
Jérôme LamySorbonne Universités, UPMC Univ Paris 06, INSERM UMRS 1146, CNRSUMR 7371, Laboratoire d'Imagerie Biomédicale, ICAN Institute of Cardiometabolism and Nutrition, Paris, France.
Alban RedheuilSorbonne Universités, UPMC Univ Paris 06, INSERM UMRS 1146, CNRSUMR 7371, Laboratoire d'Imagerie Biomédicale, ICAN Institute of Cardiometabolism and Nutrition, Paris, France.
Nadjia KachenouraSorbonne Universités, UPMC Univ Paris 06, INSERM UMRS 1146, CNRSUMR 7371, Laboratoire d'Imagerie Biomédicale, ICAN Institute of Cardiometabolism and Nutrition, Paris, France.
Greg R FulcherDepartment of Endocrinology, Royal North Shore Hospital, St Leonards, Australia.
Gemma A FigtreeSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Stuart M GrieveSydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia. stuart.grieve@sydney.edu.au.
University of Sydney · AULaboratoire d’Imagerie Biomédicale · FRCentre National de la Recherche Scientifique · FRRoyal North Shore Hospital · AUSorbonne Université · FRThe Heart Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability of magnetic resonance imaging (MRI) derived left atrial (LA) strain to detect early diastolic dysfunction in individuals with obesity and type 2 diabetes, and to explore the association between cardiac adipose tissue and LA function.

methodsTwenty patients with obesity and T2D (55 ± 8 years) and nineteen healthy controls (48 ± 13 years) were imaged using cine steady state free precession and 2-point Dixon cardiovascular magnetic resonance. LA function was quantified using a feature tracking technique with definition of phasic longitudinal strain and strain rates, as well as radial motion fraction and radial velocities.

resultsSystolic left ventricular size and function were similar between the obesity and type 2 diabetes and control groups by MRI. All patients except four had normal diastolic assessment by echocardiography. In contrast, measures of LA function using magnetic resonance feature tracking were uniformly altered in the obesity and type 2 diabetes group only. Although there was no significant difference in intra-myocardial fat fraction, Dixon 3D epicardial fat volume(EFV) was significantly elevated in the obesity and type 2 diabetes versus control group (135 ± 31 vs. 90 ± 30 mL/m

conclusionsLA MRI-strain may be a sensitive tool for the detection of early diastolic dysfunction in individuals with obesity and type 2 diabetes and correlated with BMI and epicardial fat supporting a possible association between adiposity and LA strain. Trials Registration Australian New Zealand Clinical Trials Registry No. ACTRN12613001069741.

Indexed as

Atrial Function, LeftMagnetic Resonance Imaging, CineAdipose TissueAdiposityAdultAlgorithmsCase-Control StudiesDiabetes Mellitus, Type 2DiastoleEarly DiagnosisFemaleHeart DiseasesHumansImage Interpretation, Computer-AssistedMaleMiddle AgedCardiac dysfunctionDiastolic dysfunctionFat distributionMagnetic resonance studiesObesity and type 2

Identifiers

PMID28007022
PMCPMC5178096
OpenAlexW2561607230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.