ArticleVeterinary pathology2018
Lymphocyte Subsets in the Adrenal Glands of Dogs With Primary Hypoadrenocorticism.
Article in Veterinary pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- A variant in RESF1 is associated with Addison's disease and multiple autoimmune syndrome in young Nova Scotia Duck Tolling Retrievers.Scientific reports · 2026Article
- Pharmacokinetics and pharmacodynamics of desoxycorticosterone pivalate in dogs with hypoadrenocorticism.Journal of veterinary internal medicine · 2026Article
- Genetic characterization of Addison's disease in Bearded Collies.BMC genomics · 2020Article
- DLA class II haplotypes show sex-specific associations with primary hypoadrenocorticism in Standard Poodle dogs.Immunogenetics · 2019Article
- Prevalence of hypercalcemia in primary hypoadrenocorticism in dogs: Multicenter, retrospective study.Journal of veterinary internal medicineArticle
- A case-control survey study of environmental risk factors for primary hypoadrenocorticism in dogs.Journal of veterinary internal medicineArticle
- Histopathological evaluation of the adrenal glands in a cat with primary hypoadrenocorticism and multiple endocrine disease.JFMS open reportsArticle
- Enhancement of natural killer cell activity by oral administration of a fermented soybean product in dogs.Open veterinary journalArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Primary hypoadrenocorticism, or Addison's disease, is an autoimmune condition common in certain dog breeds that leads to the destruction of the adrenal cortex and a clinical syndrome involving anorexia, gastrointestinal upset, and electrolyte imbalances. Previous studies have demonstrated that this destruction is strongly associated with lymphocytic-plasmacytic inflammation and that the lymphocytes are primarily T cells. In this study, we used both immunohistochemistry and in situ hybridization to characterize the T-cell subtypes involved. We collected postmortem specimens of 5 dogs with primary hypoadrenocorticism and 2 control dogs and, using the aforementioned techniques, showed that the lymphocytes are primarily CD4+ rather than CD8+. These findings have important implications for improving our understanding of the pathogenesis and in searching for the underlying causative genetic polymorphisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.