ArticleJournal of clinical periodontology2017
Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis.
Article in Journal of clinical periodontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Integration of periodontal pathogens and inflammatory mediators in saliva as biomarkers for periodontitis.Frontiers in cellular and infection microbiology · 2026Article
- Salivary Inflammatory Mediator Profiles in Periodontal and Peri-Implant Health and Disease: A Cross-Sectional Study.Clinical implant dentistry and related research · 2025Article
- Impact of increasedJournal of oral microbiology · 2025Article
- Comparative Analysis of Salivary and Serum Inflammatory Mediator Profiles in Patients With Rheumatoid Arthritis and Periodontitis.Mediators of inflammation · 2025Article
- Oral and Gingival Crevicular Fluid Biomarkers for Jawbone Turnover Diseases: A Scoping Review.Diagnostics (Basel, Switzerland) · 2024Article
- Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis.International journal of implant dentistry · 2022Article
- Anti-Inflammatory Effects of (3Pharmaceuticals (Basel, Switzerland) · 2022Article
- Expression and significance of mucin-4 and matrix metalloproteinase-7 in peri-implant disease.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Construction of artificial neural network diagnostic model and analysis of immune infiltration for periodontitis.Frontiers in genetics · 2022Article
- Salivary Microbiota and Host-Inflammatory Responses in Periodontitis Affected Individuals With and Without Rheumatoid Arthritis.Frontiers in cellular and infection microbiology · 2022Article
- From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues.Biomolecules · 2021Review
- Interfacial interactions of SERS-active noble metal nanostructures with functional ligands for diagnostic analysis of protein cancer markers.Mikrochimica acta · 2021Review
- A practical method to screen and identify functioning biomarkers in nasopharyngeal carcinoma.Scientific reports · 2021Article
- Periodontitis and oral cancer - current concepts of the etiopathogenesis.Oncology reviews · 2020Article
- Salivary Redox Biomarkers in Selected Neurodegenerative Diseases.Journal of clinical medicine · 2020Review
- Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis.Journal of clinical medicine · 2019Article
- Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis.Journal of clinical periodontology · 2017Article
- Comparative evaluation of mucin and total protein in periodontal disease before and after nonsurgical periodontal therapy.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPeriodontitis is a chronic inflammatory disease, characterized by irreversible destruction of tooth-supporting tissue including alveolar bone. We recently reported mucin 4 (MUC4) and matrix metalloproteinase 7 (MMP7) as highly associated with periodontitis in gingival tissue biopsies. The aim of this study was to further investigate the levels of MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) samples of patients with periodontitis. MATERIALS AND
methodsSaliva and GCF samples were collected from periodontitis patients and healthy controls. The levels of MUC4, MMP7, and total protein concentrations were analysed using ELISA or Bradford assay.
resultsMUC4 levels were significantly lower in saliva and GCF from periodontitis patients relative to healthy controls. MMP7 levels were significantly higher in saliva and GCF from periodontitis patients. Multivariate analysis revealed that MUC4 was significantly associated with periodontitis after adjusting for age and smoking habits and, moreover, that the combination of MUC4 and MMP7 accurately discriminated periodontitis from healthy controls.
conclusionsMUC4 and MMP7 may be utilized as possible novel biomarkers for periodontitis.
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