ArticleNeurotoxicity research2017
Altered Gray Matter Volume in Stable Chronic Obstructive Pulmonary Disease with Subclinical Cognitive Impairment: an Exploratory Study.
Article in Neurotoxicity research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis.Brain imaging and behavior · 2025Pooled it
- The Abnormal Alternations of Brain Imaging in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review.Journal of Alzheimer's disease reports · 2023Pooled it
- Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.Journal of internal medicine · 2026Review
- Functional reorganisation of lingual gyrus mediates cognitive impairment in COPD: a multimodal neuroimaging study.ERJ open research · 2026Article
- Bidirectional cortical gyrification alterations in chronic obstructive pulmonary disease: links to cognitive impairment and global initiative for chronic obstructive lung disease staging.BMC medical imaging · 2026Article
- Brain structural changes in COPD patients with cognitive impairment.Journal of neurology · 2026Review
- Associations among structural brain alterations, respiratory symptoms and cognitive impairment in patients with chronic obstructive pulmonary disease-related subclinical cognitive vulnerability: a multimodal neuroimaging study.Frontiers in aging neuroscience · 2026Article
- Sulcal depth-based individualized structural covariance networks reveal multi-level brain reorganization associated with cognitive performance in COPD.Frontiers in neuroscience · 2026Article
- Aberrant brain functional network in COPD patients with cognitive impairment: clinical manifestations, mechanisms and therapeutic strategies.Journal of neuroinflammation · 2025Review
- Investigation of gray matter volume in individuals with heart failure and preserved ejection fraction.Frontiers in aging neuroscience · 2025Article
- COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study.BMC pulmonary medicine · 2024Article
- Smoking related attention alteration in chronic obstructive pulmonary disease-smoking comorbidity.BMC pulmonary medicine · 2022Article
- Article
- Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study.Frontiers of medicine · 2020Article
- Article
- Abnormal intrinsic functional hubs and connectivity in stable patients with COPD: a resting-state MRI study.Brain imaging and behavior · 2020Article
- Changes in Spatial Working Memory in Stable Chronic Obstructive Pulmonary Disease: A Retrospective Study.BioMed research international · 2020Observational
- Altered amplitude of low-frequency fluctuation in basal ganglia correlates to pulmonary ventilation function in COPD patients: A resting-state fMRI study.Brain and behavior · 2019Article
- Correlations between serum amyloid A, C-reactive protein and clinical indices of patients with acutely exacerbated chronic obstructive pulmonary disease.Journal of clinical laboratory analysis · 2019Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gray matter volume deficits have been identified in cognitively impaired patients with chronic obstructive pulmonary disease (COPD). However, it remains unknown whether the gray matter volume is altered in COPD patients with subclinical cognitive impairment. To determine whether any gray matter abnormalities are present in these patients, neuropsychological tests and structural MRI data were analyzed from 60 patients with COPD and 60 age-, gender-, education-, and handedness-matched normal controls (NCs). The COPD patients had similar Mini-Mental State Examination (MMSE) scores compared with the NCs. However, they had reduced Montreal Cognitive Assessment (MoCA) scores for visuospatial and executive and naming and memory functions (P < 0.001). Voxel-based morphometry (VBM) analysis revealed that the COPD patients had significantly lowered gray matter volumes in several brain regions, including the left precuneus (PrCU), bilateral calcarine (CAL), right superior temporal gyrus/middle temporal gyrus (STG/MTG), bilateral fusiform gyrus (FG), and right inferior parietal lobule (IPL) (P < 0.01, corrected). Importantly, the forced vital capacity (FVC) was found to be associated with the gray matter volume in the calcarine. The present study confirmed that brain structural changes were present in stable COPD patients with subclinical cognitive impairment. These findings may provide new insights into the pathogenesis of COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.