ArticleScientific reports2016
Auditory biological marker of concussion in children.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Concussion acutely disrupts auditory processing in division I football student-athletes.Brain injury · 2025Article
- Sensory driven neurophysiological mechanisms of concussion: a parsimonious and falsifiable theory.Frontiers in neurology · 2025Article
- Central auditory processing is altered after traumatic brain injury in Tanzanian adults.Frontiers in neuroscience · 2025Article
- The slowest timescales of neural synchronization reveal the strongest influence of auditory distraction.Frontiers in human neuroscience · 2025Article
- Validating a novel paradigm for simultaneously assessing mismatch response and frequency-following response to speech sounds.Journal of neuroscience methods · 2024Article
- Mild Traumatic Brain Injury and the Auditory System: An Overview of the Mechanisms, Clinical Presentations, and Current Diagnostic Modalities.Journal of neurotrauma · 2024Review
- Persistent post-concussion symptoms include neural auditory processing in young children.Concussion (London, England) · 2024Article
- Clinical Gaps-in-Noise Measures in Blast-Exposed Veterans: Associations with Electrophysiological and Behavioral Responses.Seminars in hearing · 2024Review
- Periodic health evaluation in Para athletes: a position statement based on expert consensus.BMJ open sport & exercise medicine · 2024Article
- Comprehensive behavioral and physiologic assessment of peripheral and central auditory function in individuals with mild traumatic brain injury.Hearing research · 2024Article
- Detecting Central Auditory Processing Disorders in Awake Mice.Brain sciences · 2023Article
- Altered Auditory and Visual Evoked Potentials following Single and Repeated Low-Velocity Head Rotations in 4-Week-Old Swine.Biomedicines · 2023Article
- Subconcussion revealed by sound processing in the brain.Exercise, sport & movement · 2023Article
- Athleticism and sex impact neural processing of sound.Scientific reports · 2022Article
- A Home-Based Approach to Auditory Brainstem Response Measurement: Proof-of-Concept and Practical Guidelines.Seminars in hearing · 2022Review
- Neuroaudiological Considerations for the Auditory Brainstem Response and Middle Latency Response Revisited: Back to the Future.Seminars in hearing · 2022Review
- Implementation of Machine Learning on Human Frequency-Following Responses: A Tutorial.Seminars in hearing · 2022Review
- Frequency-Following Response and Auditory Behavior in Children with Prenatal Exposure to the Zika Virus.International archives of otorhinolaryngology · 2022Article
- The emergence of idiosyncratic patterns in the frequency-following response during the first year of life.JASA express letters · 2022Article
- A Retrospective Study of the Effects of Traumatic Brain Injury on Auditory Function: From a Clinical Perspective.NeuroSci · 2022Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concussions carry devastating potential for cognitive, neurologic, and socio-emotional disease, but no objective test reliably identifies a concussion and its severity. A variety of neurological insults compromise sound processing, particularly in complex listening environments that place high demands on brain processing. The frequency-following response captures the high computational demands of sound processing with extreme granularity and reliably reveals individual differences. We hypothesize that concussions disrupt these auditory processes, and that the frequency-following response indicates concussion occurrence and severity. Specifically, we hypothesize that concussions disrupt the processing of the fundamental frequency, a key acoustic cue for identifying and tracking sounds and talkers, and, consequently, understanding speech in noise. Here we show that children who sustained a concussion exhibit a signature neural profile. They have worse representation of the fundamental frequency, and smaller and more sluggish neural responses. Neurophysiological responses to the fundamental frequency partially recover to control levels as concussion symptoms abate, suggesting a gain in biological processing following partial recovery. Neural processing of sound correctly identifies 90% of concussion cases and clears 95% of control cases, suggesting this approach has practical potential as a scalable biological marker for sports-related concussion and other types of mild traumatic brain injuries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.