Evidence map›Paper›PMID 28004933›Full record

ArticleThe Journal of organic chemistry2017

Diastereoselective Synthesis of Highly Substituted Tetrahydrofurans by Pd-Catalyzed Tandem Oxidative Cyclization-Redox Relay Reactions Controlled by Intramolecular Hydrogen Bonding.

Joshua L Brooks, Liping Xu, Olaf Wiest, Derek S Tan

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joshua L BrooksChemical Biology Program , Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 422, New York, New York 10065, United StatesORCID 0000-0002-9404-8173
Liping XuSchool of Chemical Engineering, Shandong University of Technology , Zibo 255049, China.
Olaf WiestLab of Computational Chemistry and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Shenzhen 518055, China.ORCID 0000-0001-9316-7720
Derek S TanChemical Biology Program , Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 422, New York, New York 10065, United States

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
CANCER PHARMACOLOGYT32CA062948 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORRAINE J GUDAS · 1994 to 2026
$12.1M
Diversity-Oriented Synthesis of Natural Product-based Libraries for the MLSMRP41GM076267 · NIGMS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI TAN, DEREK S · 2005 to 2012
$2.7M
NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA062948NIGMS NIH HHS P41 GM076267
6 · The paper itself

Abstract

Palladium-catalyzed oxidative cyclization of alkenols provides a convenient entry into cyclic ethers but typically proceeds with little or no diastereoselectivity for cyclization of trisubstituted olefins to form tetrahydrofurans due to the similar energies of competing 5-membered transition-state conformations. Herein, a new variant of this reaction has been developed in which a PdCl

Indexed as

CatalysisCyclizationFuransHydrogen BondingMolecular ConformationOxidation-ReductionPalladiumStereoisomerismFuransPalladiumpalladium chloride

Identifiers

PMID28004933
PMCPMC5224347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.