Trial reportScientific reports2016
Molecular typing and virulence analysis of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from Egyptian hospitals.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed.
- Phenotypic and molecular detection of efflux pump and expression profiling genes in Klebsiella pneumoniae exposed to ciprofloxacin and amoxicillin/clavulanic acid.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Multidrug-resistant Klebsiella pneumoniae in oncology intensive care units: selected genetic markers and clinical predictors.Infection · 2026Article
- Clinically significant Klebsiella pneumoniae persistence in wastewater: co-occurrence of virulence and multidrug resistance genes.BMC microbiology · 2026Article
- A review on hypervirulent and multidrug-resistant Klebsiella pneumoniae: An emerging threat to human health.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Genetic variants of AcrAB and OqxAB and the impact of efflux pump inhibition on ciprofloxacin and amikacin resistance in clinical isolates of Klebsiella pneumoniae from Lima, Peru.BMC microbiology · 2026Article
- Molecular characterization of virulence and antibiotic resistance genes in Klebsiella pneumoniae isolated from sputum samples at a tertiary hospital in Ethiopia.Scientific reports · 2026Article
- Molecular Variation of Methicillin-resistantRecent patents on biotechnology · 2026Article
- Comprehensive genotypic report of carbapenem-resistant Klebsiella pneumoniae (CRKP) harboring carbapenemase-resistant genes, porin loss and efflux pump genes in Osun State, Nigeria.Molecular biology reports · 2025Article
- Genetic features of blaBMC microbiology · 2025Article
- Prevalence and genotypic-phenotypic association of highly resistant Klebsiella pneumoniae in community-acquired urinary tract infections.BMC infectious diseases · 2025Article
- Unraveling ESBL and AmpC resistance in multi-drug resistant Klebsiella pneumoniae: phenotypic and genotypic insights.Molecular biology reports · 2025Article
- Associations between carbapenemase genes, biofilm formation, and virulence factors in clinical Klebsiella pneumoniae isolates from Türkiye.Molecular biology reports · 2025Article
- Prevalence of colistin resistance in multidrug-resistantJAC-antimicrobial resistance · 2025Review
- Emergence of extensively drug-resistant Klebsiella pneumoniae from broiler chickens and clinical samples in Egypt.BMC microbiology · 2025Article
- Molecular characterization and resistance mechanisms of ertapenem-non-susceptible carbapenem-resistantJournal of bacteriology · 2025Article
- Antibiotic Resistance, Virulence Genes, and Molecular Diversity of ClinicalPathogens (Basel, Switzerland) · 2025Article
- Article
- Microbiological Quality and Presence ofMicroorganisms · 2025Article
- Virulence genes, efflux pumps, and molecular typing of Klebsiella pneumoniae isolates from North Iran.AMB Express · 2025Article
- Phenotypic and genotypic screening of multidrug resistant Klebsiella pneumoniae isolated from ready to eat street food in Tanta, Egypt.BMC microbiology · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klebsiella pneumonia infection rates have increased dramatically. Molecular typing and virulence analysis are powerful tools that can shed light on Klebsiella pneumonia infections. Whereas 77.7% (28/36) of clinical isolates indicated multidrug resistant (MDR) patterns, 50% (18/36) indicated carpabenem resistance. Gene prevalence for the AcrAB efflux pump (82.14%) was more than that of the mdtK efflux pump (32.14%) in the MDR isolates. FimH-1 and mrkD genes were prevalent in wound and blood isolates. FimH-1 gene was prevalent in sputum while mrkD gene was prevalent in urine. Serum resistance associated with outer membrane protein coding gene (traT) was found in all blood isolates. IucC, entB, and Irp-1 were detected in 32.14%, 78.5% and 10.7% of MDR isolates, respectively. We used two Polymerase Chain Reaction (PCR) analyses: Enterobacterial Repetitive Intergenic Consensus (ERIC) and Random Amplified Polymorphic DNA (RAPD). ERIC-PCR revealed 21 and RAPD-PCR revealed 18 distinct patterns of isolates with similarity ≥80%. ERIC genotyping significantly correlated with resistance patterns and virulence determinants. RAPD genotyping significantly correlated with resistance patterns but not with virulence determinants. Both RAPD and ERIC genotyping methods had no correlation with the capsule types. These findings can help up better predict MDR Klebsiella pneumoniae outbreaks associated with specific genotyping patterns.
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