Evidence map›Paper›PMID 28004701›Full record

ArticleNature communications2016

Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus.

Afif J Aqrabawi, Caleb J Browne, Zahra Dargaei, Danielle Garand, C Sahara Khademullah, Melanie A Woodin, Jun Chul Kim

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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  9. Optogenetics Neuromodulation of the Nose.Behavioural neurology · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Article
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  15. Review
  16. Article
  17. Review
  18. Brain response to odors presented inside the nose, directly in front of the nose or with ambient air.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
  19. Synaptic Organization of Anterior Olfactory Nucleus Inputs to Piriform Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Afif J AqrabawiDepartment of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
Caleb J BrowneDepartment of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3.
Zahra DargaeiDepartment of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
Danielle GarandDepartment of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
C Sahara KhademullahDepartment of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
Melanie A WoodinDepartment of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.ORCID 0000-0003-2984-8630
Jun Chul KimDepartment of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.

Indexed as

AnimalsBacterial ProteinsBehavior, AnimalCyanatesGreen Fluorescent ProteinsHippocampusLuminescent ProteinsMaleMiceMice, Inbred C57BLOlfactory CortexOlfactory PathwaysOptogeneticsRed Fluorescent ProteinSmellBacterial ProteinsCyanatesGreen Fluorescent ProteinsLuminescent ProteinsRed Fluorescent Proteinyellow fluorescent protein, Bacteria

Identifiers

PMID28004701
PMCPMC5192165
OpenAlexW2562446262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.