ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2017
Beyond force generation: Why is a dynamic ring of FtsZ polymers essential for bacterial cytokinesis?
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Non canonical perspectives on AmpR mediated ampC expression in Gram negative bacteria, with particular emphasis on the potential regulatory purview of FtsZ.World journal of microbiology & biotechnology · 2026Review
- Queuosine biosynthetic enzyme, QueE moonlights as a cell division regulator.PLoS genetics · 2024Article
- Antimicrobial activity of a natural compound and analogs against multi-drug-resistant Gram-positive pathogens.Microbiology spectrum · 2024Article
- Integration of cell wall synthesis and chromosome segregation during cell division in Caulobacter.The Journal of cell biology · 2024Article
- Membrane rigidity regulates E. coli proliferation rates.Scientific reports · 2022Article
- PdpC, a secreted effector protein of the type six secretion system, is required for erythrocyte invasion byFrontiers in cellular and infection microbiology · 2022Article
- Impact of FtsZ Inhibition on the Localization of the Penicillin Binding Proteins in Methicillin-Resistant Staphylococcus aureus.Journal of bacteriology · 2021Article
- FtsZ induces membrane deformations via torsional stress upon GTP hydrolysis.Nature communications · 2021Article
- Cell division in the archaeon Haloferax volcanii relies on two FtsZ proteins with distinct functions in division ring assembly and constriction.Nature microbiology · 2021Article
- Progression of the late-stage divisome is unaffected by the depletion of the cytoplasmic FtsZ pool.Communications biology · 2021Article
- Artificial modulation of cell width significantly affects the division time of Escherichia coli.Scientific reports · 2020Article
- Insights into the Structure, Function, and Dynamics of the Bacterial Cytokinetic FtsZ-Ring.Annual review of biophysics · 2020Review
- Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins.Nature microbiology · 2020Article
- Synthetic cell division via membrane-transforming molecular assemblies.BMC biology · 2019Review
- Movement dynamics of divisome proteins and PBP2x:FtsW in cells ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Gain-of-function variants of FtsA form diverse oligomeric structures on lipids and enhance FtsZ protofilament bundling.Molecular microbiology · 2018Article
- Escherichia coli ZipA Organizes FtsZ Polymers into Dynamic Ring-Like Protofilament Structures.mBio · 2018Article
- Article
- Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division.F1000Research · 2018Review
- Turgor Pressure and Possible Constriction Mechanisms in Bacterial Division.Frontiers in microbiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We propose that the essential function of the most highly conserved protein in bacterial cytokinesis, FtsZ, is not to generate a mechanical force to drive cell division. Rather, we suggest that FtsZ acts as a signal-processing hub to coordinate cell wall synthesis at the division septum with a diverse array of cellular processes, ensuring that the cell divides smoothly at the correct time and place, and with the correct septum morphology. Here, we explore how the polymerization properties of FtsZ, which have been widely attributed to force generation, can also be advantageous in this signal processing role. We suggest mechanisms by which FtsZ senses and integrates both mechanical and biochemical signals, and conclude by proposing experiments to investigate how FtsZ contributes to the remarkable spatial and temporal precision of bacterial cytokinesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.