Evidence map›Paper›PMID 28004395›Full record

ArticleClinical cardiology2017

Myocardial tissue deformation is reduced in subjects with coronary microvascular dysfunction but not rescued by treatment with ranolazine.

Michael D Nelson, Behzad Sharif, Jaime L Shaw, Galen Cook-Wiens, Janet Wei, Chrisandra Shufelt, Puja K Mehta, Louise E J Thomson, Daniel S Berman, Richard B Thompson and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Myocardial biomarkers in coronary microvascular dysfunction: Response to ranolazine.American heart journal plus : cardiology research and practice · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Michael D NelsonApplied Physiology and Advanced Imaging Laboratory, University of Texas at Arlington, Arlington, Texas.
Behzad SharifBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Jaime L ShawBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Galen Cook-WiensBiostatistics Core, Cedars-Sinai Medical Center, Los Angeles, California.
Janet WeiBarbra Streisand Women's Heart Center, Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Chrisandra ShufeltBarbra Streisand Women's Heart Center, Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Puja K MehtaBarbra Streisand Women's Heart Center, Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Louise E J ThomsonMark S. Taper Imaging Center, Cedars-Sinai Medical Center, Los Angeles, California.
Daniel S BermanEmory Women's Heart Center, Emory University School of Medicine, Atlanta, Georgia.
Richard B ThompsonDepartment of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Eileen M HandbergDivision of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, Florida.
Carl J PepineDivision of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, Florida.
Debiao LiBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
C Noel Bairey MerzBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Cedars-Sinai Medical Center · USCedars-Sinai Smidt Heart Institute · USFlorida College · USImaging Center · USUniversity of Alberta · CAUniversity of Florida · US

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Quantitative Prediction of Disease and Outcomes from Next Generation SPECT and CTR01HL089765 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SLOMKA, PIOTR J · 2007 to 2021
$6.1M
ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTERN01HV068163 · HV · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 1996 to 2001
$386k
ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CENTERN01HV068161 · HV · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROGERS, WILLIAM J · 1996 to 2000
$245k
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTRN01HV068164 · HV · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI REICHEK, NATHANIEL · 1996 to 2001
–
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR-N01HV68162-268068162N01HV068162 · HV · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2005
–
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001427NCRR NIH HHS M01 RR000425NCRR NIH HHS UL1 RR033176NHLBI NIH HHS N01 HV068161NHLBI NIH HHS N01 HV068162NHLBI NIH HHS N01 HV068163NHLBI NIH HHS N01 HV068164NHLBI NIH HHS R01 HL089765
6 · The paper itself

Abstract

backgroundPatients with coronary microvascular dysfunction (CMD) often have diastolic dysfunction, representing an important therapeutic target. Ranolazine-a late sodium current inhibitor-improves diastolic function in animal models and subjects with obstructive coronary artery disease (CAD). HYPOTHESIS: We hypothesized that ranolazine would beneficially alter diastolic function in CMD.

methodsTo test this hypothesis, we performed retrospective tissue tracking analysis to evaluate systolic/diastolic strain, using cardiac magnetic resonance imaging cine images acquired in a recently completed, randomized, double-blind, placebo-controlled, crossover trial of short-term ranolazine in subjects with CMD and from 43 healthy reference controls.

resultsDiastolic strain rate was impaired in CMD vs controls (circumferential diastolic strain rate: 99.9% ± 2.5%/s vs 120.1% ± 4.0%/s, P = 0.0003; radial diastolic strain rate: -199.5% ± 5.5%/s vs -243.1% ± 9.6%/s, P = 0.0008, case vs control). Moreover, peak systolic circumferential strain (CS) and radial strain (RS) were also impaired in cases vs controls (CS: -18.8% ± 0.3% vs -20.7% ± 0.3%; RS: 35.8% ± 0.7% vs 41.4% ± 0.9%; respectively; both P < 0.0001), despite similar and preserved ejection fraction. In contrast to our hypothesis, however, we observed no significant changes in left ventricular diastolic function in CMD cases after 2 weeks of ranolazine vs placebo.

conclusionsThe case-control comparison both confirms and extends our prior observations of diastolic dysfunction in CMD. That CMD cases were also found to have subclinical systolic dysfunction is a novel finding, highlighting the utility of this retrospective approach. In contrast to previous studies in obstructive CAD, ranolazine did not improve diastolic function in CMD.

Indexed as

AdultAgedCardiovascular AgentsClinical Trials as TopicCoronary Artery DiseaseCoronary CirculationCoronary VesselsDiastoleFemaleHumansMagnetic Resonance Imaging, CineMaleMicrocirculationMicrovesselsMiddle AgedMyocardiumCardiovascular AgentsRanolazineSodium Channel BlockersCoronary microvascular dysfunctionmicrovascular ischemiaranolazinetissue tracking

Identifiers

PMID28004395
PMCPMC5436931
OpenAlexW2563430883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.