ArticlePharmaceutical research2017
Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging.
Article in Pharmaceutical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Article
- Quality by Design and Process Analytical Technology for On-Demand Drug Manufacturing Through 3D Printing.Pharmaceutics · 2026Review
- Microstructure and Mechanical Performance of 3D-Printed Carbon Fibre-PLA-PHA Composites.Polymers · 2026Article
- Structured engineering of self-emulsifying drug delivery systems (SEDDS)International journal of pharmaceutics: X · 2025Review
- Article
- Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery.Pharmaceutics · 2023Article
- Characterization of Pharmaceutical Tablets by X-ray Tomography.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development, Filament Extrusion, Printing Process and Printer Design.Therapeutic innovation & regulatory science · 2022Review
- Three-Dimensional Printing of a Container Tablet: A New Paradigm for Multi-Drug-Containing Bioactive Self-Nanoemulsifying Drug-Delivery Systems (Bio-SNEDDSs).Pharmaceutics · 2022Article
- A 3D-Printed Polymer-Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations.Pharmaceutics · 2021Article
- Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion.Molecules (Basel, Switzerland) · 2021Article
- The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM).Pharmaceutics · 2021Article
- Degradation of 3D-Printed Porous Polylactic Acid Scaffolds Under Mechanical Stimulus.Frontiers in bioengineering and biotechnology · 2021Article
- Measuring Open Porosity of Porous Materials Using THz-TDS and an Index-Matching Medium.Sensors (Basel, Switzerland) · 2020Article
- Personalised 3D Printed Medicines: Optimising Material Properties for Successful Passive Diffusion Loading of Filaments for Fused Deposition Modelling of Solid Dosage Forms.Pharmaceutics · 2020Article
- Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron.Pharmaceutics · 2020Article
- The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality.Pharmaceutics · 2019Review
- Article
- 3D Printing in Pharmaceutical and Medical Applications - Recent Achievements and Challenges.Pharmaceutical research · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA 3D printer was used to realise compartmental dosage forms containing multiple active pharmaceutical ingredient (API) formulations. This work demonstrates the microstructural characterisation of 3D printed solid dosage forms using X-ray computed microtomography (XμCT) and terahertz pulsed imaging (TPI).
methodsPrinting was performed with either polyvinyl alcohol (PVA) or polylactic acid (PLA). The structures were examined by XμCT and TPI. Liquid self-nanoemulsifying drug delivery system (SNEDDS) formulations containing saquinavir and halofantrine were incorporated into the 3D printed compartmentalised structures and in vitro drug release determined.
resultsA clear difference in terms of pore structure between PVA and PLA prints was observed by extracting the porosity (5.5% for PVA and 0.2% for PLA prints), pore length and pore volume from the XμCT data. The print resolution and accuracy was characterised by XμCT and TPI on the basis of the computer-aided design (CAD) models of the dosage form (compartmentalised PVA structures were 7.5 ± 0.75% larger than designed; n = 3).
conclusionsThe 3D printer can reproduce specific structures very accurately, whereas the 3D prints can deviate from the designed model. The microstructural information extracted by XμCT and TPI will assist to gain a better understanding about the performance of 3D printed dosage forms.
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