Trial reportClinical oral investigations2017
Efficacy of desensitizing products containing 8% arginine and calcium carbonate for hypersensitivity relief in MIH-affected molars: an 8-week clinical study.
Trial report in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Desensitization treatment in MIH-affected teeth: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Pooled it
- An update of treatment modalities in children and adolescents with teeth affected by molar incisor hypomineralisation (MIH): a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Pooled it
- Pooled it
- Management of initial carious lesions of hypomineralized molars (MIH) with silver diamine fluoride or silver-modified atraumatic restorative treatment (SMART): 1-year results of a prospective, randomized clinical trial.Clinical oral investigations · 2022Trial
- Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial.Journal of applied oral science : revista FOB · 2022Trial
- Efficacy of a Toothpaste Based on Microcrystalline Hydroxyapatite on Children with Hypersensitivity Caused by MIH: A Randomised Controlled Trial.Oral health & preventive dentistry · 2021Trial
- A child-centred measure of tooth hypersensitivity for molar incisor hypomineralisation (MIH-TH): development and psychometric evaluation.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Lived Experiences of Tooth Hypersensitivity in Children With Molar Incisor Hypomineralisation.International journal of paediatric dentistry · 2026Article
- Comparison of different cavity patterns and treatment methods in molars with molar-incisor hypomineralization (MIH) - retrospective 9 months results.BMC oral health · 2026Article
- Key concepts for clinical management of Molar Incisor Hypomineralization.Brazilian oral research · 2026Review
- In vitro study of high-power Er: YAG laser parameters for the management of dentin hypersensitivity in hypomineralized permanent teeth.Lasers in medical science · 2025Article
- Efficiency of glass ionomer sealant application in reducing hypersensitivity in MIH-molars in schoolchildren immediately and after 12 weeks.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Comparison of Patient Acceptance and Caregiver Satisfaction of Glass-Ionomer Cement vs. Silver Fluoride/Potassium Iodide Application to Manage Molar Incisor Hypomineralisation Hypersensitivity Immediately and After 12 Weeks.Clinics and practice · 2025Article
- Non-Invasive Strategies for Remineralization and Hypersensitivity Management in Molar-Incisor Hypomineralization-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- The level of dental fear and anxiety is higher in children with both severe Molar-Incisor Hypomineralisation and active dental caries lesions compared to children without these conditions.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Observational
- Molar Incisor Hypomineralization: Optimizing Treatment Protocols for Hypersensitivity: A Randomized Clinical Trial.Dentistry journal · 2024Article
- Molar incisor hypomineralization and oral health-related quality of life: a sample of 8-12-years-old children.Clinical oral investigations · 2024Article
- Contemporary Understanding of the Etiology and Management of Molar Incisor Hypomineralization: A Literature Review.Dentistry journal · 2023Review
- Article
- Association of dental hypersensitivity and anxiety in children with molar-incisor hypomineralisation (MIH).European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of this study was to compare the efficacy in reducing hypersensitivity in molar incisor hypomineralization (MIH)-affected molars immediately and over 8 weeks combining a single in-office application and a homed-based program with desensitizing products containing 8% arginine and calcium carbonate. MATERIALS AND
methodsNineteen children with at least one MIH-affected molar with hypersensitivity were included. Hypersensitivity was assessed with an evaporative (air) stimulus and a tactile stimulus. Each child received a single in-office treatment with a desensitizing paste containing 8% arginine and calcium carbonate (elmex Sensitive Professional desensitizing paste), followed by 8 weeks of brushing twice daily with a desensitizing toothpaste containing 8% arginine, calcium carbonate with 1450 ppm fluoride (elmex Sensitive Professional toothpaste), using the elmex Sensitive Professional toothbrush. Additionally, the corresponding mouthwash (elmex Sensitive Professional mouthwash) was used. Clinical assessments were made at baseline, immediately after the in-office treatment and after 1, 2, 4 and 8 weeks of brushing twice daily.
resultsFifty-six molars with an air blast hypersensitivity score of 2 or 3 (Schiff Cold Air Sensitivity Scale) were included. Application of the desensitizing paste decreased hypersensitivity significantly immediately and throughout the 8 weeks recalls (p < 0.001).
conclusionsIn conclusion, 8% arginine and calcium carbonate were able to reduce hypersensitivity successfully during this 8-week trial. CLINICAL RELEVANCE: Hypersensitivity is a major complaint in patients with MIH. This is the first study evaluating the desensitizing effect of a desensitizing paste containing 8% arginine and calcium carbonate in patients with MIH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.