SynthesisArchives of gynecology and obstetrics2017
Lymphocyte immunotherapy in the treatment of recurrent miscarriage: systematic review and meta-analysis.
Synthesis in Archives of gynecology and obstetrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Immunotherapy and IVF Outcomes in Unexplained Recurrent Pregnancy Loss: A Systematic Review with Implications for Personalized Reproductive Medicine.Journal of personalized medicine · 2025Review
- Role of belimumab in recurrent spontaneous abortions amongst patients with lymphocyte dysfunction: a retrospective case-control study.BMC pregnancy and childbirth · 2025Article
- Maternal-Fetal Compatibility in Recurrent Pregnancy Loss.Journal of clinical medicine · 2024Review
- Adverse drug reactions following lymphocyte immunotherapy for the treatment of infertility: A retrospective study.The journal of obstetrics and gynaecology research · 2022Article
- Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion.Immunity, inflammation and disease · 2021Article
- Analysis of parental abnormal chromosomal karyotype and subsequent live births in Chinese couples with recurrent pregnancy loss.Scientific reports · 2021Article
- Live Birth Rates after Active Immunization with Partner Lymphocytes.Biomedicines · 2021Article
- Safety of lymphocytes immunotherapy during the COVID-19 outbreak in Wuhan, China.Archives of gynecology and obstetrics · 2021Article
- Immunological Risk Factors in Recurrent Pregnancy Loss: Guidelines Versus Current State of the Art.Journal of clinical medicine · 2021Review
- COVID-19 and immunomodulation treatment for women with reproductive failures.Journal of reproductive immunology · 2020Review
- Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded byFrontiers in immunology · 2020Article
- Changes in Gut Microorganism in Patients with Positive Immune Antibody-Associated Recurrent Abortion.BioMed research international · 2020Article
- Gestational and perinatal outcomes in recurrent miscarriages couples treated with lymphocyte immunotherapy.European journal of obstetrics & gynecology and reproductive biology: X · 2019Article
- Outbreak of HIV Infection Linked to Nosocomial Transmission, China, 2016-2017.Emerging infectious diseases · 2018Article
- Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/050).Geburtshilfe und Frauenheilkunde · 2018Article
- Active Immunisation with Partner Lymphocytes in Female Patients Who Want to Become Pregnant - Current Status.Geburtshilfe und Frauenheilkunde · 2018Article
- Maternal natural killer cell immunoglobulin receptor genes and human leukocyte antigen-C ligands influence recurrent spontaneous abortion in the Han Chinese population.Experimental and therapeutic medicine · 2018Article
- Low-dose lymphocyte immunotherapy rebalances the peripheral blood Th1/Th2/Treg paradigm in patients with unexplained recurrent miscarriage.Reproductive biology and endocrinology : RB&E · 2017Article
- Novel Association of Thrombophilic PROS1, PROC and CPB2 Genes Polymorphisms with Recurrent Spontaneous Miscarriage Women in Jordan.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
- Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3Journal of human reproductive sciencesArticle
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecurrent miscarriage (RM) affects up to 2-3% of couples of reproductive age. There are several causes for this condition, including immunologic. The embryo is considered an allograft, subject to the rejection mechanisms of the maternal immune system. Immunotherapy involving immunization with lymphocytes is considered in cases of idiopathic RM. However, there is still no consensus regarding the efficacy and safety of this therapy.
methodsThis systematic review and meta-analysis evaluated the data available in the literature regarding the efficacy and safety of the use of immunotherapy with lymphocytes in couples with history of RM. Searches in PubMed/Medline, SCOPUS, and Cochrane Library databases were conducted, using the following keywords: "recurrent miscarriage," "lymphocyte immunotherapy," and "meta-analysis." Statistical analyses were performed using Review Manager 5.3 (RevMan), version 5.3.
resultsSix published meta-analysis were retrieved; two found no improvements in the rate of live births after the use of immunization with lymphocytes in the treatment of RM, and four found a beneficial effect of the use of immunotherapy with lymphocytes in cases of RM, with significant improvements in the rate of live births.
conclusionData available in the literature supports the efficacy and safety of immunotherapy with lymphocytes in cases of RM without an identified cause.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.