ReviewInternational journal of ophthalmology2016
Biomechanics of the sclera and effects on intraocular pressure.
Review in International journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Biological mechanisms of atropine in myopia control (Review).Molecular medicine reports · 2026Pooled it
- Efficacy and safety of prostaglandin analogues in primary open-angle glaucoma or ocular hypertension patients: A meta-analysis.Medicine · 2019Pooled it
- Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study.Matrix biology plus · 2026Article
- 3.75 THz Repetitive Radiation Regulates Collagen Metabolism in Human Fetal Scleral Fibroblasts.Cells · 2026Article
- Short-Term Impact of Scleral Lens Wear on Intraocular Pressure and Retinal Nerve Fiber Layer Thickness.Life (Basel, Switzerland) · 2026Article
- Spatiotemporal Mapping of Biomechanical Stress Predicts Region-Specific Retinal Injury in a Murine Model of Blunt Ocular Trauma.Bioengineering (Basel, Switzerland) · 2026Article
- Influence of body position and time of day on ocular rhythms.Scientific reports · 2025Article
- Asymmetric stress distribution on lamina cribrosa in glaucoma patients with high myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- A review of mechanism of action of outdoor exposure in preventing myopia incidence and progression.International journal of ophthalmology · 2024Review
- An Inverse Method to Determine Mechanical Parameters of Porcine Vitreous Bodies Based on the Indentation Test.Bioengineering (Basel, Switzerland) · 2023Article
- Biomechanics of open-globe injury: a review.Biomedical engineering online · 2023Review
- Opto-mechanical self-adjustment model of the human eye.Biomedical optics express · 2023Article
- Computational Modeling of Ophthalmic Procedures: Computational Modeling of Ophthalmic Procedures.American journal of ophthalmology · 2022Article
- Targeting the NLRP3 Inflammasome in Glaucoma.Biomolecules · 2021Review
- Corneal Hysteresis in Thais and Variation of Corneal Hysteresis in Glaucoma.Clinical optometry · 2021Article
- The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters.BMC ophthalmology · 2020Article
- Alterations in proteome of human sclera associated with primary open-angle glaucoma involve proteins participating in regulation of the extracellular matrix.Molecular vision · 2020Article
- The mechanical theory of glaucoma in terms of prelaminar, laminar, and postlaminar factors.Taiwan journal of ophthalmologyReview
- Comparison of Ocular Biomery in Primary Open Angle Glaucoma and Non-glaucoma in South West Nigeria.Journal of the West African College of SurgeonsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence indicates that glaucoma is a multifactorial neurodegenerative disease characterized by the loss of retinal ganglion cells (RGC), resulting in gradual and progressive permanent loss of vision. Reducing intraocular pressure (IOP) remains the only proven method for preventing and delaying the progression of glaucomatous visual impairment. However, the specific role of IOP in optic nerve injury remains controversial, and little is known about the biomechanical mechanism by which elevated IOP leads to the loss of RGC. Published studies suggest that the biomechanical properties of the sclera and scleral lamina cribrosa determine the biomechanical changes of optic nerve head, and play an important role in the pathologic process of loss of RGC and optic nerve damage. This review focuses on the current understanding of biomechanics of sclera in glaucoma and provides an overview of the possible interactions between the sclera and IOP. Treatments and interventions aimed at the sclera are also discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.