ArticleInternational journal of ophthalmology2016
Incidence of orbital, conjunctival and lacrimal gland malignant tumors in USA from Surveillance, Epidemiology and End Results, 1973-2009.
Article in International journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Cancers Attributable to Infections in the US in 2017: A Meta-Analysis.JAMA oncology · 2023Pooled it
- Outcomes of malignant orbital tumors: a 22-year Norwegian single-center series.Frontiers in surgery · 2026Article
- Population-Based Incidence and Clinical Characteristics of Ocular Adnexal Tumors in Olmsted County, Minnesota.Ophthalmic epidemiology · 2025Article
- Trends in utilization of imaging among ophthalmic-related emergency department visits in the United States.Frontiers in ophthalmology · 2025Article
- Epidemiology of orbital diseases in a tertiary ophthalmic outpatient clinic in Sao Paulo, Brazil.Arquivos brasileiros de oftalmologia · 2025Article
- Incidental Diagnosis of Four Lid Orbital Lymphoma during a Blepharoplasty.Plastic and reconstructive surgery. Global open · 2024Article
- Declining incidence and improving survival of ocular and orbital lymphomas in the US between 1995 and 2018.Scientific reports · 2024Article
- Ophthalmic Manifestations in Patients with Blood Malignancies.Hematology reports · 2024Review
- Epidemiology and tumor microenvironment of ocular surface and orbital tumors on growth and malignant transformation.Frontiers in oncology · 2024Review
- Incidence and clinical characteristics of pediatric ocular tumors in a Midwestern US population.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2023Article
- A joinpoint and age-period-cohort analysis of ocular cancer secular trends in Iran from 2004 to 2016.Scientific reports · 2023Article
- The clinicopathological analysis of ocular and orbit tumors in southeast of China.Frontiers in oncology · 2023Article
- Roles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base.Laryngoscope investigative otolaryngology · 2021Article
- Orbital mold brachytherapy for recurrent orbital mesenchymal chondrosarcoma: a case report.Journal of contemporary brachytherapy · 2021Article
- Serum markers change for intraocular metastasis in renal cell carcinoma.Bioscience reports · 2021Article
- Clinico-epidemiological analysis of 1000 cases of orbital tumors.Japanese journal of ophthalmology · 2021Article
- A case report of secondary bilateral orbital lymphoma in a child.Radiology case reports · 2021Article
- Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Low-Dose RadiotherapyFrontiers in oncology · 2021Article
- Evolution of Care of Orbital Tumors with Radiation Therapy.Journal of neurological surgery. Part B, Skull base · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the types and incidence of tumors affecting the orbit, conjunctiva and lacrimal glands and to study the trend line of these tumors in the United States from 1973 to 2009.
methodsWe used the publicly available Surveillance, Epidemiology and End Results (SEER) database registries to determine the incidence rates. Age was adjusted to the 2000 US Standard Population. Patients were stratified according to age group, gender, race and histological grouping of tumor lesions. Three age groups were defined: 0-19, 20-49 and ≥50y. Annual percentage changes were calculated to examine trends.
resultsThe overall age adjusted incidence rate was 3.39 (95%CI: 3.27-3.52) per million person-years. The tumors were more prevalent in age group ≥50 counting 9.51 (95%CI: 9.11-9.92) per million person-years. Most of the soft tissue sarcomas occurred in the young age with incidence rate of 0.35 (95%CI: 0.28-0.42) per million person-years. Lymphomas were the dominant subtype in the adult population with incidence rate of 5.74 (95%CI: 5.43-6.06) per million person-years. Incidence rates were higher in males than females with an overall rate ratio of 1.31 (95%CI: 1.21-1.41) mainly caused by the increase in carcinoma subtypes. White race had a higher tumor incidence with a rate ratio of 1.47(95%CI: 1.25-1.73) driven by the higher incidence of most histological subtypes. Orbital tumors showed a higher incidence rate followed by conjunctival and lacrimal gland tumors with incidence rates of 1.59, 1.37 and 0.43 per million person-years respectively. The trend line of overall incidence of tumors showed a significant increase (APC=3.11, 95%CI: 2.61-3.61) mainly due to increase of lymphomas. This increase was higher than the increase of lymphomas at other sites.
conclusionOrbital, conjunctival and lacrimal gland malignant tumors differ among children and adults. Over the years there has been a noticeable increase in incidence rates of orbital and lacrimal gland tumors mainly caused by an increase in lymphomas and an apparent increase due to advances in diagnostic techniques. ICD-O-3 topographical coding should be improved to consider the different orbital bones and ocular structures.
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