ArticleNeuroImage. Clinical2017
Structural alterations of the brainstem in migraine.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.Molecular psychiatry · 2026Pooled it
- The genetic architecture of brainstem structures.Nature communications · 2025Pooled it
- Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Trial
- Risk Factors and Consequences of Cutaneous Allodynia among Individuals with Migraine: A Scoping Review.Current pain and headache reports · 2025Article
- Imaging the Brainstem Raphe in Medication-Overuse Headache: Pathophysiological Insights and Implications for Personalized Care.Biomedicines · 2025Article
- Beyond Pain: The Effects of OnabotulinumtoxinA Therapy on Sensitization and Interictal Symptoms in Chronic Migraine.Toxins · 2024Review
- Review
- Longitudinal differences in iron deposition in periaqueductal gray matter and anterior cingulate cortex are associated with response to erenumab in migraine.Cephalalgia : an international journal of headache · 2023Article
- Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients.Frontiers in neuroscience · 2023Article
- The value of brain MRI functional connectivity data in a machine learning classifier for distinguishing migraine from persistent post-traumatic headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research.Frontiers in neurology · 2022Review
- Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study.BMC neurology · 2021Article
- Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia.PloS one · 2021Article
- Disrupted White Matter Functional Connectivity With the Cerebral Cortex in Migraine Patients.Frontiers in neuroscience · 2021Article
- Interictal pontine metabolism in migraine without aura patients: A 3 Tesla proton magnetic resonance spectroscopy study.NeuroImage. Clinical · 2021Article
- Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition.Brain sciences · 2020Article
- Patients With Vestibular Migraine are More Likely to Have Occipital Headaches than those With Migraine Without Vestibular Symptoms.Headache · 2020Article
- Mechanisms of migraine as a chronic evolutive condition.The journal of headache and pain · 2019Review
- Structural changes of cerebellum and brainstem in migraine without aura.The journal of headache and pain · 2019Article
- Cortical spreading depression as a site of origin for migraine: Role of CGRP.Cephalalgia : an international journal of headache · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Atypical brainstem modulation of pain might contribute to changes in sensory processing typical of migraine. The study objective was to investigate whether migraine is associated with brainstem structural alterations that correlate with this altered pain processing. MRI T1-weighted images of 55 migraine patients and 58 healthy controls were used to: (1) create deformable mesh models of the brainstem that allow for shape analyses; (2) calculate volumes of the midbrain, pons, medulla and the superior cerebellar peduncles; (3) interrogate correlations between regional brainstem volumes, cutaneous heat pain thresholds, and allodynia symptoms. Migraineurs had smaller midbrain volumes (healthy controls = 61.28 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.