Evidence map›Paper›PMID 28003846›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2016

Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke.

Jinpei Lin, Fei Xu, Genfa Wang, Lingwen Kong, Qingli Luo, Yvbao Lv, Jiaqi Liu, Ying Wei, Lulu Li, Hongying Zhang and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  3. Evolution of radiation-induced dermatitis treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
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  13. Evidence-based complementary and alternative medicine : eCAM · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jinpei LinDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
Fei XuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
Genfa WangDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
Lingwen KongDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
Qingli LuoDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.ORCID 0000-0001-6173-353X
Yvbao LvDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
Jiaqi LiuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
Ying WeiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.ORCID 0000-0002-7519-6867
Lulu LiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
Hongying ZhangDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.ORCID 0000-0002-0614-2152
Jingcheng DongDepartment of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.ORCID 0000-0002-3645-0324
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.

Identifiers

PMID28003846
PMCPMC5149678
OpenAlexW2558762309

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.