Evidence map›Paper›PMID 28003811›Full record

ArticleFrontiers in immunology2016

Identification and Characterization of a Novel Association between Dietary Potassium and Risk of Crohn's Disease and Ulcerative Colitis.

Hamed Khalili, Sakshi Malik, Ashwin N Ananthakrishnan, John J Garber, Leslie M Higuchi, Amit Joshi, Joanna Peloquin, James M Richter, Kathleen O Stewart, Gary C Curhan and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Hamed KhaliliDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.
Sakshi MalikTranslational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad , India.
Ashwin N AnanthakrishnanDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.
John J GarberDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
Leslie M HiguchiDivision of Gastroenterology and Nutrition, Boston Children's Hospital, Harvard Medical School , Boston, MA , USA.
Amit JoshiDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.
Joanna PeloquinDivision of Gastroenterology and Hepatology, Johns Hopkins School of Medicine , Baltimore, MD , USA.
James M RichterDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
Kathleen O StewartDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
Gary C CurhanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
Amit AwasthiTranslational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad , India.
Vijay YajnikDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USMassachusetts General Hospital · USTranslational Health Science and Technology Institute · INJohns Hopkins University · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Oral Contraceptives in the Etiopathogenesis of Crohn's DiseaseK23DK099681 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KHALILI, HAMED · 2013 to 2017
$946k
NIDDK NIH HHS K23 DK099681NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

backgroundRecent animal studies have identified that dietary salt intake may modify the risk and progression of autoimmune disorders through modulation of the IL-23/T

methodsWe conducted a prospective study of U.S. women enrolled in the Nurses' Health Study (NHS) and NHSII who provided detailed and validated information on diet and lifestyle beginning in 1984 in NHS and 1991 in NHSII. We confirmed incident cases of UC and CD reported through 2010 in NHS and 2011 in NHSII. We used Cox proportional hazards models to calculate hazard ratios and 95% confidence intervals. In a case-control study nested within these cohorts, we evaluated the interaction between single nucleotide polymorphisms (SNPs) in genes involved in T

resultsAmong a total of 194,711 women over a follow-up of 3,220,247 person-years, we documented 273 cases of CD and 335 cases of UC. Dietary intake of potassium (

conclusionDietary potassium is inversely associated with risk of CD with both

Indexed as

Crohn’s diseasedietary potassiumimmune toleranceinflammatory bowel diseaseNurses’ Health StudyTH17 pathwayulcerative colitis

Identifiers

PMID28003811
PMCPMC5141241
OpenAlexW2560622060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.