ArticleMolecular vision2016
A regulatory sequence from the
Article in Molecular vision, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- An enhancer located in a Pde6c intron drives transient expression in the cone photoreceptors of developing mouse and human retinas.Developmental biology · 2022Article
- MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma.Oncogenesis · 2022Article
- Early cis-regulatory events in the formation of retinal horizontal cells.Developmental biology · 2021Article
- Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors.Development (Cambridge, England) · 2021Article
- High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy.Frontiers in molecular biosciences · 2020Article
- Lineage tracing analysis of cone photoreceptor associated cis-regulatory elements in the developing chicken retina.Scientific reports · 2019Article
- Quantitative analysis of the ThrbCRM1-centered gene regulatory network.Biology open · 2019Article
- Heterogeneity in retinoblastoma: a tale of molecules and models.Clinical and translational medicine · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCombining techniques of episomal vector gene-specific Cre expression and genomic integration using the piggyBac transposon system enables studies of gene expression-specific cell lineage tracing in the chicken retina. In this work, we aimed to target the retinal horizontal cell progenitors.
methodsA 208 bp gene regulatory sequence from the chicken
resultsCells that drove Cre expression from the regulatory RXRγ208 sequence excised the floxed STOP-sequence and expressed GFP. The approach generated a stable lineage with robust expression of GFP in retinal cells that have activated transcription from the RXRγ208 sequence. Furthermore, GFP was expressed in cells that express horizontal or photoreceptor markers when electroporation was performed between developmental stages 22 and 28. Electroporation of a stage 12 optic cup gave multiple cell types in accordance with
conclusionsIn this study, we describe an easy, cost-effective, and time-efficient method for testing regulatory sequences in general. More specifically, our results open up the possibility for further studies of the
Indexed as
Identifiers
28003731PMC5166796W2565140378What OpenQuestion holds
Registered trials
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