Evidence map›Paper›PMID 28003720›Full record

ArticleJournal of clinical and experimental hepatology2016

Role of Diffusion Weighted Imaging (DWI) for Hepatocellular Carcinoma (HCC) Detection and its Grading on 3T MRI: A Prospective Study.

Shiva Shankar, Naveen Kalra, Anmol Bhatia, Radhika Srinivasan, Paramjeet Singh, Radha K Dhiman, Niranjan Khandelwal, Yogesh Chawla

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In one paragraph

Article in Journal of clinical and experimental hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. [European journal of nuclear medicine and molecular imaging · 2025
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  17. Updates on Imaging of Liver Tumors.Current oncology reports · 2020
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  20. [Research progress of magnetic resonance imaging in hepatocellular carcinoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shiva ShankarDepartment of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Naveen KalraDepartment of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Anmol BhatiaDepartment of Gastroenterology, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Radhika SrinivasanDepartment of Cytology and Gynaecological Pathology, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Paramjeet SinghDepartment of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Radha K DhimanDepartment of Hepatology, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Niranjan KhandelwalDepartment of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Yogesh ChawlaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited studies have evaluated the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) for histologically grading the hepatocellular carcinoma (HCC).

objectiveTo compare the efficacy of DWI with dynamic contrast enhanced magnetic resonance (DCEMR) in detection of HCC in cirrhosis, and to evaluate whether DWI can be used instead of DCEMR.

methods20 patients of either sex with cirrhosis and suspected of having HCC on screening USG were included in this prospective study approved by the Institutional Ethics Committee. All patients underwent DCEMR of the abdomen on 3T scanner and fine needle aspiration of the lesions. MR protocol included T1WI, T2WI, DWI, and dynamic CEMR. The results of diffusion weighted imaging were compared with DCEMR to find the efficacy of DWI vis-à-vis CEMR.

resultsDWI had a sensitivity and specificity of 100%, for diagnosis of lesions in cases having single lesion on CEMR, and sensitivity of 75% and specificity of 100% for diagnosis of lesions in cases having multiple lesions. There was a decreasing trend of ADC values with increasing grade of the tumor; however, the decreasing trend was not statistically significant. A cut-off ADC value of 0.8705 resulted in a sensitivity of 75% and specificity of 50% for differentiating between well-differentiated and other grades of HCC.

conclusionDWI can be used as an alternative for the detection and characterization of HCC, especially in patients with impaired renal function or contrast allergies precluding the use of contrast. In addition, DWI with ADC measurement may be helpful for non-invasive and preoperative prediction of the degree of differentiation of HCC.

Indexed as

ADCADC, apparent diffusion coefficientDCEMRDCEMR, dynamic contrast enhanced magnetic resonanceDWIDWI, diffusion weighted imaginggradingHASTE, half-Fourier acquisition single-shot turbo spin echoHCCHCC, hepatocellular carcinomaTSE, turbo spin echoVIBE, volume interpolated breath hold examination

Identifiers

PMID28003720
PMCPMC5157886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.