Evidence map›Paper›PMID 28003717›Full record

ArticleJournal of clinical and experimental hepatology2016

Noninvasive Assessment of Liver Fibrosis By Transient Elastography and FIB4/APRI for Prediction of Treatment Response in Chronic Hepatitis C-An Experience from a Tertiary Care Hospital.

Sunil Taneja, Sunil Tohra, Ajay Duseja, Radha Krishan Dhiman, Yogesh Kumar Chawla

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Diagnostic performance of non-invasive liver fibrosis risk scores in biopsy-proven non-alcoholic fatty liver disease patients in India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. [Clinical study of FibroTouch and six serological models for assessing the degree of liver fibrosis in patients with chronic hepatitis B].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2019
    Article
  12. Observational
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sunil TanejaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Sunil TohraDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Ajay DusejaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Radha Krishan DhimanDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Yogesh Kumar ChawlaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver fibrosis and its sequel cirrhosis represent a major health care burden, and assessment of fibrosis by biopsy is gradually being replaced by noninvasive methods. In clinical practice, the determination of fibrosis stage is important, since patients with advanced fibrosis have faster progression to cirrhosis and antiviral therapy is indicated in these patients.

aimsTo assess the role of transient elastography (TE) and compare it with APRI and FIB4 for predicting liver fibrosis and assessing the effect of host and viral factors on fibrosis and treatment outcome in CHC patients.

methodsIn a retrospective analysis, 330 CHC patients underwent liver stiffness measurement (LSM) by TE and tests needed for calculating APRI and FIB4 scores at baseline. 228 patients received a combination of Pegylated IFN-based antiviral therapy and were analyzed for therapeutic response.

resultsThe study included 330 patients (median age 39 years [range 18-67]), predominantly males (

conclusionThe study shows that LSM by TE and fibrosis assessment by FIB4/APRI scores can be used with fair reliability to predict fibrosis and treatment response in patients with CHC infection.

Indexed as

ALT, alanine transaminasesAPRI, AST to Platelet ratio indexAST, aspartate transaminasesBMI, body mass indexCHB, chronic hepatitis Bchronic hepatitis CCLD, chronic liver diseaseDM, diabetes mellitusETR, end of treatment responseEVR, early virological responseFIB4, fibrosis-4 scoreHCV, hepatitis CIQR/M, interquartile range/mediankPa, kilopascalsLB, liver biopsyLF, liver fibrosisliver biopsyliver fibrosisLSM, liver stiffness measurementnoninvasive markersNPV, negative predictive valuePEG INF, Pegylated InterferonPPV, positive predictive valueRBV, RibavarinRGT, response guided treatmentROC, receiver operating characteristicRVR, rapid virological responseSVR, sustained virological responseTE, transient elastographytransient elastography

Identifiers

PMID28003717
PMCPMC5157918
OpenAlexW2512016797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.