ReviewHypertension research : official journal of the Japanese Society of Hypertension2017
Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview.
Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Trial
- Methoxyacetic acid exposure in rats induces N-butyrylglycinuria consistent with beta-oxidation impairment.Archives of toxicology · 2026Article
- Association between fish-related metabolites and metabolic syndrome risk factors in Japan: INTERLIPID metabolome -wide association study.European journal of nutrition · 2026Observational
- Metabolomics analysis of pathways underlying radiation-induced salivary gland dysfunction stages.PloS one · 2023Article
- Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives.Frontiers in molecular biosciences · 2021Review
- Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan.PloS one · 2021Observational
- Proportional changes in the gut microbiome: a risk factor for cardiovascular disease and dementia?Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.American journal of epidemiology · 2019Article
- Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients.Scientific reports · 2019Article
- Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Review
- Beyond genomics: understanding exposotypes through metabolomics.Human genomics · 2018Review
- Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry.PloS one · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The etiopathogenesis of cardiovascular diseases (CVDs) is multifactorial. Adverse blood pressure (BP) is a major independent risk factor for epidemic CVD affecting ~40% of the adult population worldwide and resulting in significant morbidity and mortality. Metabolic phenotyping of biological fluids has proven its application in characterizing low-molecular-weight metabolites providing novel insights into gene-environmental-gut microbiome interaction in relation to a disease state. In this review, we synthesize key results from the INTERnational study of MAcro/micronutrients and blood Pressure (INTERMAP) Study, a cross-sectional epidemiologic study of 4680 men and women aged 40-59 years from Japan, the People's Republic of China, the United Kingdom and the United States. We describe the advancements we have made regarding the following: (1) analytical techniques for high-throughput metabolic phenotyping; (2) statistical analyses for biomarker identification; (3) discovery of unique food-specific biomarkers; and (4) application of metabolome-wide association studies to gain a better understanding into the molecular mechanisms of cross-cultural and regional BP differences.
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Registered trials
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