Evidence map›Paper›PMID 28003503›Full record

ArticleNeurology2017

Parallel recovery of consciousness and sleep in acute traumatic brain injury.

Catherine Duclos, Marie Dumont, Caroline Arbour, Jean Paquet, Hélène Blais, David K Menon, Louis De Beaumont, Francis Bernard, Nadia Gosselin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Boundary-Dependent Sleep-Wake Dysregulation in Idiopathic Hypersomnia.Annals of clinical and translational neurology · 2026
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  18. Validity of actigraphy for nighttime sleep monitoring in hospitalized patients with traumatic injuries.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Catherine DuclosFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada.
Marie DumontFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada.
Caroline ArbourFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada.
Jean PaquetFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada.
Hélène BlaisFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada.
David K MenonFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada.
Louis De BeaumontFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada.
Francis BernardFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada.
Nadia GosselinFrom the Center for Advanced Research in Sleep Medicine (C.D., M.D., C.A., J.P., H.B., L.D.B., N.G.) and the Traumatology Program (F.B.), Hôpital du Sacré-Coeur de Montréal; Departments of Psychiatry (C.D., M.D.), Psychology (C.A., N.G.), and Medicine (F.B.), Université de Montréal, Canada; Division of Anaesthesia (D.K.M.), University of Cambridge, UK; and Department of Psychology (L.D.B.), Université du Québec à Trois-Rivières, Canada. nadia.gosselin@umontreal.ca.
Université du Québec à Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether the progressive recuperation of consciousness was associated with the reconsolidation of sleep and wake states in hospitalized patients with acute traumatic brain injury (TBI).

methodsThis study comprised 30 hospitalized patients (age 29.1 ± 13.5 years) in the acute phase of moderate or severe TBI. Testing started 21.0 ± 13.7 days postinjury. Consciousness level and cognitive functioning were assessed daily with the Rancho Los Amigos scale of cognitive functioning (RLA). Sleep and wake cycle characteristics were estimated with continuous wrist actigraphy. Mixed model analyses were performed on 233 days with the RLA (fixed effect) and sleep-wake variables (random effects). Linear contrast analyses were performed in order to verify if consolidation of the sleep and wake states improved linearly with increasing RLA score.

resultsAssociations were found between scores on the consciousness/cognitive functioning scale and measures of sleep-wake cycle consolidation (p < 0.001), nighttime sleep duration (p = 0.018), and nighttime fragmentation index (p < 0.001). These associations showed strong linear relationships (p < 0.01 for all), revealing that consciousness and cognition improved in parallel with sleep-wake quality. Consolidated 24-hour sleep-wake cycle occurred when patients were able to give context-appropriate, goal-directed responses.

conclusionsOur results showed that when the brain has not sufficiently recovered a certain level of consciousness, it is also unable to generate a 24-hour sleep-wake cycle and consolidated nighttime sleep. This study contributes to elucidating the pathophysiology of severe sleep-wake cycle alterations in the acute phase of moderate to severe TBI.

Indexed as

SleepActigraphyActivities of Daily LivingAcute DiseaseAdolescentAdultBrain Injuries, TraumaticCognitionConsciousnessFemaleGlasgow Coma ScaleHospitalizationHumansIntensive Care UnitsMaleRecovery of Function

Identifiers

PMID28003503
PMCPMC5272791
OpenAlexW2564936791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.