Evidence map›Paper›PMID 28003490›Full record

ArticleJournal of virology2017

Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L.

Stephen A Goldstein, Joshua M Thornbrough, Rong Zhang, Babal K Jha, Yize Li, Ruth Elliott, Katherine Quiroz-Figueroa, Annie I Chen, Robert H Silverman, Susan R Weiss

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. tRNA modifications in viral replication.The Journal of biological chemistry · 2026
    Review
  6. Article
  7. Article
  8. Human coronaviruses: activation and antagonism of innate immune responses.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  9. Automated annotation and validation of human respiratory virus sequences using VADR.Database : the journal of biological databases and curation · 2025
    Article
  10. Article
  11. Article
  12. Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Stephen A GoldsteinDepartment of Microbiology, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Joshua M ThornbroughDepartment of Microbiology, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Rong ZhangDepartment of Microbiology, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Babal K JhaDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID http://orcid.org/0000-0002-7660-5255
Yize LiDepartment of Microbiology, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ruth ElliottDepartment of Microbiology, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Katherine Quiroz-FigueroaDepartment of Microbiology, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Annie I ChenDepartment of Microbiology, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert H SilvermanDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Susan R WeissDepartment of Microbiology, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA weisssr@upenn.edu.ORCID http://orcid.org/0000-0002-8155-4528
University of Pennsylvania · USCleveland Clinic Lerner College of Medicine · US

Funding

Control of Viral Pathogenesis by Regulation of 2-5A LevelsR01AI104887 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SILVERMAN, ROBERT H., WEISS, SUSAN R · 2013 to 2023
$7.6M
TRAINING IN VIROLOGYT32AI007324 · NIAID · WISTAR INSTITUTE · PI Paul Bates, Matthew D. Weitzman · 1989 to 2026
$6.8M
Control of coronavirus pathogenesis by antagonism of RNase LR21AI114920 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WEISS, SUSAN R · 2015 to 2016
$454k
Coronavirus Antagonism of the OAS-RNase L PathwayF32AI114143 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI THORNBROUGH, JOSHUA MATHEW · 2015 to 2015
$46k
NIAID NIH HHS F32 AI114143NIAID NIH HHS R01 AI104887NIAID NIH HHS R21 AI114920NIAID NIH HHS T32 AI007324
6 · The paper itself

Abstract

Viruses in the family

Indexed as

Adenine NucleotidesAmino Acid SequenceAnimalsCatalytic DomainCell LineConserved SequenceCricetinaeEndoribonucleasesEnzyme ActivationMacrophagesMiceMice, Inbred C57BLMice, KnockoutMiddle East Respiratory Syndrome CoronavirusMurine hepatitis virusOligoribonucleotides2-5A-dependent ribonuclease2',5'-oligoadenylateAdenine NucleotidesEndoribonucleasesOligoribonucleotidesPhosphoric Diester HydrolasesViral Nonstructural Proteinsinterferon antagonistlineage A coronavirusoligoadenylate synthetasephosphodiesteraseRNase Ltorovirus

Identifiers

PMID28003490
PMCPMC5309944
OpenAlexW2565031426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.