Evidence map›Paper›PMID 28003480›Full record

ArticleJournal of virology2017

Nonstructural Protein 4 of Porcine Reproductive and Respiratory Syndrome Virus Modulates Cell Surface Swine Leukocyte Antigen Class I Expression by Downregulating β2-Microglobulin Transcription.

Pengfei Qi, Ke Liu, Jianchao Wei, Yuming Li, Beibei Li, Donghua Shao, Zhuanchang Wu, Yuanyuan Shi, Guangzhi Tong, Yafeng Qiu and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Pengfei QiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Ke LiuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Jianchao WeiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Yuming LiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Beibei LiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Donghua ShaoShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Zhuanchang WuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Yuanyuan ShiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Guangzhi TongShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Yafeng QiuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China yafengq@shvri.ac.cn zhiyongma@shvri.ac.cn.
Zhiyong MaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China yafengq@shvri.ac.cn zhiyongma@shvri.ac.cn.
Shanghai Veterinary Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of PRRS, which has important impacts on the pig industry. PRRSV infection results in disruption of the swine leukocyte antigen class I (SLA-I) antigen presentation pathway. In this study, highly pathogenic PRRSV (HP-PRRSV) infection inhibited transcription of the β2-microglobulin (β2M) gene (

Indexed as

Animalsbeta 2-MicroglobulinCell LineDown-RegulationGene ExpressionGene SilencingHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHost-Pathogen InteractionsPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusPromoter Regions, GeneticProteasome Endopeptidase ComplexProtein BindingProteolysisSus scrofabeta 2-MicroglobulinHistocompatibility Antigens Class IHistocompatibility Antigens Class IIProteasome Endopeptidase Complexswine leukocyte antigenViral Nonstructural ProteinsNsp4porcine B2M promoterporcine reproductive and respiratory syndrome virusPRRSVSLA-Iβ2-microglobulin

Identifiers

PMID28003480
PMCPMC5309937
OpenAlexW2565619044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.