ArticleProceedings. Biological sciences2016
Antibody responses to avian influenza viruses in wild birds broaden with age.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Structural and functional characterization of the antigenicity of influenza A virus hemagglutinin subtype H15.Cell reports · 2026Article
- Interannual differences in common eider duck exposure to avian influenza viruses at an Arctic colony.Conservation physiology · 2026Article
- Host responses and viral traits interact to shape the impacts of climate warming on highly pathogenic avian influenza in migratory waterfowl.PLoS computational biology · 2025Article
- Exposure and survival of wild raptors during the 2022-2023 highly pathogenic influenza a virus outbreak.Scientific reports · 2025Article
- Association of poultry vaccination with interspecies transmission and molecular evolution of H5 subtype avian influenza virus.Science advances · 2025Article
- Asymptomatic infection and antibody prevalence to co-occurring avian influenza viruses vary substantially between sympatric seabird species following H5N1 outbreaks.Scientific reports · 2025Article
- Wild Florida mottled ducks demonstrate strong heterogeneity in their humoral innate immune response.PloS one · 2025Article
- Divergent age-related changes in parasite infection occur independently of behaviour and demography in a wild ungulate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Avian influenza virus circulation and immunity in a wild urban duck population prior to and during a highly pathogenic H5N1 outbreak.Veterinary research · 2024Article
- Highly Pathogenic H5N1 Influenza A Virus (IAV) in Blue-Winged Teal in the Mississippi Flyway Is Following the Historic Seasonal Pattern of Low-Pathogenicity IAV in Ducks.Pathogens (Basel, Switzerland) · 2024Article
- Assessment of Survival Kinetics for Emergent Highly Pathogenic Clade 2.3.4.4 H5Nx Avian Influenza Viruses.Viruses · 2024Article
- Longitudinal Active Avian Influenza Surveillance in Bangladesh From 2017-2022 Reveals Differential IAV and H5 Infection and Viral Burden Associated With Bird Species, Sex, and Age.Transboundary and emerging diseases · 2024Article
- North American wintering mallards infected with highly pathogenic avian influenza show few signs of altered local or migratory movements.Scientific reports · 2023Article
- Impact of host age on viral and bacterial communities in a waterbird population.The ISME journal · 2023Article
- Strong host phylogenetic and ecological effects on host competency for avian influenza in Australian wild birds.Proceedings. Biological sciences · 2023Article
- Avian influenza antibody prevalence increases with mercury contamination in wild waterfowl.Proceedings. Biological sciences · 2022Article
- Spatiotemporal changes in influenza A virus prevalence among wild waterfowl inhabiting the continental United States throughout the annual cycle.Scientific reports · 2022Article
- Variations in immune parameters with age in a wild rodent population and links with survival.Ecology and evolution · 2022Article
- Naturally Acquired Antibodies to Influenza A Virus in Fall-Migrating North American Mallards.Veterinary sciences · 2022Article
- Response of three local chicken ecotypes of Ghana to lentogenic and velogenic Newcastle disease virus challenge.Tropical animal health and production · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
For viruses such as avian influenza, immunity within a host population can drive the emergence of new strains by selecting for viruses with novel antigens that avoid immune recognition. The accumulation of acquired immunity with age is hypothesized to affect how influenza viruses emerge and spread in species of different lifespans. Despite its importance for understanding the behaviour of avian influenza viruses, little is known about age-related accumulation of immunity in the virus's primary reservoir, wild birds. To address this, we studied the age structure of immune responses to avian influenza virus in a wild swan population (Cygnus olor), before and after the population experienced an outbreak of highly pathogenic H5N1 avian influenza in 2008. We performed haemagglutination inhibition assays on sampled sera for five avian influenza strains and show that breadth of response accumulates with age. The observed age-related distribution of antibody responses to avian influenza strains may explain the age-dependent mortality observed during the highly pathogenic H5N1 outbreak. Age structures and species lifespan are probably important determinants of viral epidemiology and virulence in birds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.