Evidence map›Paper›PMID 28003377›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

Leonie Brockmann, Nicola Gagliani, Babett Steglich, Anastasios D Giannou, Jan Kempski, Penelope Pelczar, Maria Geffken, Bechara Mfarrej, Francis Huber, Johannes Herkel and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 110 citations in OpenAlex.

  1. Trial
  2. Depletion of LAG-3Clinical pharmacology and therapeutics · 2021
    Trial
  3. Regulatory T cells: From Foxp3 to tolerance-inducing therapies.The Journal of investigative dermatology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Peptides Derived from α-Tubulin Induce Functional T Regulatory Cells.International journal of molecular sciences · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. IL-27-induced PD-L1Experimental & molecular medicine · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Tolerogenic dendritic cells generatedFrontiers in immunology · 2023
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Leonie BrockmannI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.
Nicola GaglianiI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.
Babett SteglichI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.
Anastasios D GiannouI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.
Jan KempskiI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.ORCID 0000-0001-8867-5077
Penelope PelczarI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.
Maria GeffkenInstitut für Transfusionsmedizin, Zentrum für Diagnostik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.
Bechara MfarrejDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.ORCID 0000-0002-8361-5240
Francis HuberI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.
Johannes HerkelI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany.
Yisong Y WanDepartment of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599.
Enric EspluguesDepartment of Immunobiology, Yale University, School of Medicine, New Haven, CT 06510.
Manuela BattagliaDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.ORCID 0000-0003-4535-3152
Christian F KrebsIII. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany; and.
Richard A FlavellDepartment of Immunobiology, Yale University, School of Medicine, New Haven, CT 06510; richard.flavell@yale.edu shuber@uke.de.ORCID 0000-0003-4461-0778
Samuel HuberI.Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany; richard.flavell@yale.edu shuber@uke.de.
University Medical Center Hamburg-Eppendorf · DEVita-Salute San Raffaele University · ITHoward Hughes Medical Institute · USUniversität Hamburg · DEUniversity of North Carolina at Chapel Hill · USYale University · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Functional protein networks underlying T cell growth, proliferation and differentiationR01AI123193 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yisong Wan · 2017 to 2026
$3.8M
The roles of Gata3 in controlling Treg functionR01AI097392 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WAN, YISONG · 2012 to 2016
$1.8M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA016086NCI NIH HHS P30 CA016359NIAID NIH HHS R01 AI097392NIAID NIH HHS R01 AI123193
6 · The paper itself

Abstract

IL-10 is essential to maintain intestinal homeostasis. CD4

Indexed as

AnimalsInterleukin-10MiceMice, Inbred C57BLp38 Mitogen-Activated Protein KinasesPhosphorylationReceptors, Interleukin-10Signal TransductionSTAT3 Transcription FactorTh17 CellsT-Lymphocytes, RegulatoryInterleukin-10p38 Mitogen-Activated Protein KinasesReceptors, Interleukin-10Stat3 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID28003377
PMCPMC5263184
OpenAlexW2582791402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.