Evidence map›Paper›PMID 28003368›Full record

ArticleThe Journal of biological chemistry2017

UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase.

Andrea Braganza, Jianfeng Li, Xuemei Zeng, Nathan A Yates, Nupur B Dey, Joel Andrews, Jennifer Clark, Leila Zamani, Xiao-Hong Wang, Claudette St Croix and 4 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
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  14. NADNAR cancer · 2021
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  16. Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
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  19. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Andrea BraganzaFrom the Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Jianfeng Lithe Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Xuemei ZengBiomedical Mass Spectrometry Center, School of the Health Sciences, and.
Nathan A Yatesthe Hillman Cancer Center, University of Pittsburgh Cancer Institute.
Nupur B Deythe Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Joel Andrewsthe Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Jennifer Clarkthe Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Leila Zamanithe Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Xiao-Hong Wangthe Hillman Cancer Center, University of Pittsburgh Cancer Institute.
Claudette St CroixDepartment of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.
Roderick O'SullivanFrom the Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Laura Garcia-ExpositoFrom the Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Jeffrey L Brodskythe Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Robert W SobolFrom the Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, rwsobol@health.southalabama.edu.ORCID 0000-0001-7385-3563
University of Pittsburgh · USUSA Mitchell Cancer Institute · USUPMC Hillman Cancer Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Inhibition of the ALT pathway by interfering with Poly-ADP-Ribose metabolismR01CA207209 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Roderick O'Sullivan · 2016 to 2026
$3.6M
Novel approaches to enhance tumor cell cytotoxicity of alkylating agentsR01CA148629 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI SOBOL, ROBERT W · 2010 to 2021
$3.4M
ER Associated Degradation of Membrane Proteins in YeastR01GM075061 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L. · 2006 to 2019
$3.2M
DNA repair deficient cells for analysisR44GM087798 · NIGMS · TREVIGEN, INC. · PI GEORGE, JAY, SOBOL, ROBERT W · 2010 to 2011
$2.5M
DNA repair deficient human cells for genomic variation analysisR43GM087798 · NIGMS · TREVIGEN, INC. · PI GEORGE, JAY, SOBOL, ROBERT W · 2009 to 2009
$200k
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA148629NCI NIH HHS R01 CA207209NIDDK NIH HHS P30 DK079307NIGMS NIH HHS R01 GM075061NIGMS NIH HHS R43 GM087798NIGMS NIH HHS R44 GM087798
6 · The paper itself

Abstract

Recent genome-wide studies found that patients with hypotonia, developmental delay, intellectual disability, congenital anomalies, characteristic facial dysmorphic features, and low cholesterol levels suffer from

Indexed as

Amino Acid SequenceCalmodulinCell Line, TumorCell ProliferationGene Knockdown TechniquesHumansMitochondriaSequence Homology, Amino AcidUbiquitin-Protein LigasesCalmodulinUBE3B protein, humanUbiquitin-Protein LigasescalciumHECTKaufman oculocerebrofacial syndromemitochondriaoxidative stressprotein degradationreactive oxygen species (ROS)super-resolution microscopyubiquitin/proteosome systemubiquitylation (ubiquitination)

Identifiers

PMID28003368
PMCPMC5313114
OpenAlexW2564588200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.