Evidence map›Paper›PMID 28003344›Full record

ReviewJournal of neurology, neurosurgery, and psychiatry2017

Differentiating lower motor neuron syndromes.

Nidhi Garg, Susanna B Park, Steve Vucic, Con Yiannikas, Judy Spies, James Howells, William Huynh, José M Matamala, Arun V Krishnan, John D Pollard and 3 more

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurology, neurosurgery, and psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05048862 (The Neuroimage Study of the Neuromuscular Disorders.), which is not on this map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05048862 recruitingnot on this mapstarted 2021, after this paper: background citation

The Neuroimage Study of the Neuromuscular Disorders.

Typeobservational_patient_registrySponsorNational Taiwan University HospitalRan2021 to 2031Enrolled500ConditionsNeuromuscular DiseasesArmsNeuromuscular ultrasound, Muscle MRI, Nerve conduction studies and autonomic function tests, Quantitative sensory test, Skin biopsy
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 127 citations in OpenAlex.

  1. Myopathies in clinical care: a focus on treatable causes.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Article
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  4. Review
  5. Review
  6. Clinical and neurophysiological characterization of p.Gly59Ser mutation in DCTN1: a study in a Thai family and a brief review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Advances in diagnosis and management of distal sensory polyneuropathies.Journal of neurology, neurosurgery, and psychiatry · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Nidhi GargBrain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Susanna B ParkBrain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Steve VucicDepartments of Neurology and Neurophysiology, Westmead Hospital, The University of Sydney, Sydney, New South Wales, Australia.
Con YiannikasDepartment of Neurology, Concord and Royal North Shore Hospitals, The University of Sydney, Sydney, New South Wales, Australia.
Judy SpiesBrain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
James HowellsBrain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
William HuynhBrain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
José M MatamalaBrain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Arun V KrishnanPrince of Wales Clinical School, The University of New South Wales, Sydney, New South Wales, Australia.
John D PollardBrain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
David R CornblathDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Mary M ReillyMRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology, London, UK.
Matthew C KiernanBrain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
The University of Sydney · AUJohns Hopkins University · USNational Hospital for Neurology and Neurosurgery · GBUNSW Sydney · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lower motor neuron (LMN) syndromes typically present with muscle wasting and weakness and may arise from pathology affecting the distal motor nerve up to the level of the anterior horn cell. A variety of hereditary causes are recognised, including spinal muscular atrophy, distal hereditary motor neuropathy and LMN variants of familial motor neuron disease. Recent genetic advances have resulted in the identification of a variety of disease-causing mutations. Immune-mediated disorders, including multifocal motor neuropathy and variants of chronic inflammatory demyelinating polyneuropathy, account for a proportion of LMN presentations and are important to recognise, as effective treatments are available. The present review will outline the spectrum of LMN syndromes that may develop in adulthood and provide a framework for the clinician assessing a patient presenting with predominantly LMN features.

Indexed as

Anterior Horn CellsAutoantibodiesDiagnosis, DifferentialDNA Mutational AnalysisHumansMotor Neuron DiseaseMotor NeuronsMuscular Atrophy, SpinalPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingSyndromeAutoantibodiesGENETICSMOTOR NEURON DISEASENEUROIMMUNOLOGYNEUROPATHYNEUROPHYSIOLOGY

Identifiers

PMID28003344
PMCPMC5529975
OpenAlexW2565735485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.