Evidence map›Paper›PMID 28003336›Full record

ArticleEMBO molecular medicine2017

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina.

Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz-Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Sialylation in the nervous system: Functions and mechanisms.The Journal of biological chemistry · 2026
    Review
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  18. Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Marcus KarlstetterLaboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.
Jens KopatzInstitute of Reconstructive Neurobiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Alexander AslanidisLaboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.
Anahita ShahrazInstitute of Reconstructive Neurobiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Albert CaramoyLaboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.
Bettina Linnartz-GerlachInstitute of Reconstructive Neurobiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Yuchen LinLeibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Anika LückoffLaboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.
Sascha FauserLaboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.
Katharina DükerInstitute of Reconstructive Neurobiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Janine ClaudeInstitute of Reconstructive Neurobiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Yiner WangInstitute of Reconstructive Neurobiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Johannes AckermannInstitute of Reconstructive Neurobiology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Tobias SchmidtInstitute of Molecular Medicine, University Hospital Bonn, University of Bonn, Bonn, Germany.
Veit HornungInstitute of Molecular Medicine, University Hospital Bonn, University of Bonn, Bonn, Germany.
Christine SkerkaLeibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Thomas LangmannLaboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany thomas.langmann@uk-koeln.de hneuman1@uni-bonn.de.ORCID 0000-0001-6826-529X
Harald NeumannInstitute of Reconstructive Neurobiology, University Hospital Bonn, University of Bonn, Bonn, Germany thomas.langmann@uk-koeln.de hneuman1@uni-bonn.de.ORCID 0000-0002-5071-5202
University of Bonn · DEUniversity of Cologne · DELeibniz Association · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a major cause of blindness in the elderly population. Its pathophysiology is linked to reactive oxygen species (ROS) and activation of the complement system. Sialic acid polymers prevent ROS production of human mononuclear phagocytes via the inhibitory sialic acid-binding immunoglobulin-like lectin-11 (SIGLEC11) receptor. Here, we show that low-dose intravitreal injection of low molecular weight polysialic acid with average degree of polymerization 20 (polySia avDP20) in humanized transgenic mice expressing SIGLEC11 on mononuclear phagocytes reduced their reactivity and vascular leakage induced by laser coagulation. Furthermore, polySia avDP20 prevented deposition of the membrane attack complex in both SIGLEC11 transgenic and wild-type animals. In vitro, polySia avDP20 showed two independent, but synergistic effects on the innate immune system. First, polySia avDP20 prevented tumor necrosis factor-α, vascular endothelial growth factor A, and superoxide production by SIGLEC11-positive phagocytes. Second, polySia avDP20 directly interfered with complement activation. Our data provide evidence that polySia avDP20 ameliorates laser-induced damage in the retina and thus is a promising candidate to prevent AMD-related inflammation and angiogenesis.

Indexed as

Complement ActivationAnimalsChoroidal NeovascularizationHumansImmunologic FactorsLasersLectinsMembrane ProteinsMice, SCIDMice, TransgenicPhagocytesRetinaSialic AcidsImmunologic FactorsLectinsMembrane Proteinspolysialic acidSialic AcidsSIGLEC11 protein, humanage‐related macular degenerationcomplementmicrogliapolysialic acidSIGLEC

Identifiers

PMID28003336
PMCPMC5286381
OpenAlexW2564292429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.